Voluntary adolescent alcohol exposure does not robustly increase adulthood consumption of alcohol in multiple mouse and rat models.

Autor: Sicher AR; Neuroscience Graduate Program, The Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Liss A; Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA., Vozella V; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Marsland P; Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA., Seemiller LR; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Springer M; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Starnes WD; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Griffith KR; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA., Smith GC; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA., Astefanous A; Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA., Deak T; Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA., Roberto M; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA., Varodayan FP; Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA., Crowley NA; Neuroscience Graduate Program, The Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biology, The Pennsylvania State University, University Park, PA, 16802, USA.; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 21. Date of Electronic Publication: 2024 Jul 21.
DOI: 10.1101/2024.04.30.591674
Abstrakt: Adolescence is a period of increased risk taking, including increased alcohol and drug use. Multiple clinical studies report a positive relationship between adolescent alcohol consumption and risk of developing an alcohol use disorder (AUD) in adulthood. However, few preclinical studies have attempted to tease apart the biological contributions of adolescent alcohol exposure, independent of other social, environmental, and stress factors, and studies that have been conducted show mixed results. Here we use several adolescent voluntary consumption of alcohol models, conducted across four labs in three institutes and with two rodent species, to investigate the ramifications of adolescent alcohol consumption on adulthood alcohol consumption in controlled, pre-clinical environments. We consistently demonstrate a lack of robust increases in adulthood alcohol consumption. This work highlights that risks seen in both human datasets and other murine drinking models may be due to unique social and environmental factors - some of which may be unique to humans.
Databáze: MEDLINE