Macrovascular blood flow and microvascular cerebrovascular reactivity are regionally coupled in adolescence.

Autor:	Zvolanek KM; Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL, USA., Moore JE; Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL, USA.; Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Jarvis K; Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Moum SJ; Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA., Bright MG; Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, IL, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 04. Date of Electronic Publication: 2024 Oct 04.
DOI:	10.1101/2024.04.26.590312
Abstrakt:	Cerebrovascular imaging assessments are particularly challenging in adolescent cohorts, where not all modalities are appropriate, and rapid brain maturation alters hemodynamics at both macro- and microvascular scales. In a preliminary sample of healthy adolescents (n=12, 8-25 years), we investigated relationships between 4D flow MRI-derived blood velocity and blood flow in bilateral anterior, middle, and posterior cerebral arteries and BOLD cerebrovascular reactivity in associated vascular territories. As hypothesized, higher velocities in large arteries are associated with an earlier response to a vasodilatory stimulus (cerebrovascular reactivity delay) in the downstream territory. Higher blood flow through these arteries is associated with a larger BOLD response to a vasodilatory stimulus (cerebrovascular reactivity amplitude) in the associated territory. These trends are consistent in a case study of adult moyamoya disease. In our small adolescent cohort, macrovascular-microvascular relationships for velocity/delay and flow/CVR change with age, though underlying mechanisms are unclear. Our work emphasizes the need to better characterize this key stage of human brain development, when cerebrovascular hemodynamics are changing, and standard imaging methods offer limited insight into these processes. We provide important normative data for future comparisons in pathology, where combining macro- and microvascular assessments may better help us prevent, stratify, and treat cerebrovascular disease. Competing Interests: Declaration of Conflicting Interest The Authors declare that there is no conflict of interest.
Databáze:	MEDLINE
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