Analysis of coagulation factors in angioedema/urticaria: increased values of D-dimer and fibrinogen in isolated angioedema.

Autor:	Štrajtenberger M; Department of Pulmonology, Special Hospital for Pulmonary Diseases, Zagreb, Croatia., Lugović-Mihić L; Department of Dermatology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia.; School of Dental Medicine, University of Zagreb, Zagreb, Croatia., Stipić-Marković A; Department of Pulmonology, Special Hospital for Pulmonary Diseases, Zagreb, Croatia., Artuković M; Department of Pulmonology, Special Hospital for Pulmonary Diseases, Zagreb, Croatia.; Osijek Faculty of Dental Medicine and Health, Osijek, Croatia., Mihić R; Department of Clinical Chemistry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia., Dolački L; Institute of Emergency Medicine of Zagreb County, Velika Gorica, Croatia., Pravica NB; Department of Emergency Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia., Lokner I; Department of Pulmonology, Special Hospital for Pulmonary Diseases, Zagreb, Croatia.; Department of Laboratory Diagnostics, Department of Pulmonology, Special Hospital for Pulmonary Diseases, Zagreb, Croatia.
Jazyk:	angličtina
Zdroj:	Acta dermatovenerologica Alpina, Pannonica, et Adriatica [Acta Dermatovenerol Alp Pannonica Adriat] 2024 Jun; Vol. 33 (2), pp. 63-68.
Abstrakt:	Introduction: Recent research has shown that blood coagulation and the extrinsic coagulation cascade are involved in the pathogenesis of chronic spontaneous urticaria (CSU), but little is known about the coagulation factors in angioedema. Methods: This study included 58 participants: 29 patients with chronic angioedema (14 with isolated angioedema and 15 with angioedema with wheals) and 29 healthy controls (HCs). We compared the values of coagulation factors in patients with isolated angioedema to those with wheals. Plasma levels of D-dimer, fibrinogen, and factor VII were measured by enzyme-linked immunosorbent assay (ELISA) for all participants. Results: Significantly higher D-dimer (p = 0.016; ε² = 0.381) and fibrinogen (p = 0.044; ε² = 0.331) levels were recorded in patients with angioedema (both groups) than in the HCs, with higher levels for angioedema with wheals. Factor VII and fibrinogen levels did not differ significantly between the groups with angioedema, but coagulation factors were more often elevated in both angioedema groups than in HCs. Conclusions: One characteristic of angioedema is an elevated blood coagulation potential, which may help produce fibrin and may be important in controlling angioedema attacks.
Databáze:	MEDLINE
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