Role of radiomics as a predictor of disease recurrence in ovarian cancer: a systematic review.

Autor: O'Sullivan NJ; Department of Radiology, St. James's Hospital, Dublin, Ireland. nosulli7@tcd.ie.; School of Medicine, Trinity College Dublin, Dublin, Ireland. nosulli7@tcd.ie.; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland. nosulli7@tcd.ie., Temperley HC; Department of Surgery, St. James's Hospital, Dublin, Ireland., Horan MT; Department of Radiology, St. James's Hospital, Dublin, Ireland.; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland., Kamran W; Department of Gynaecology, St. James's Hospital, Dublin, Ireland., Corr A; Department of Radiology, St. James's Hospital, Dublin, Ireland., O'Gorman C; Department of Gynaecology, St. James's Hospital, Dublin, Ireland., Saadeh F; Department of Gynaecology, St. James's Hospital, Dublin, Ireland., Meaney JM; Department of Radiology, St. James's Hospital, Dublin, Ireland.; School of Medicine, Trinity College Dublin, Dublin, Ireland.; The National Centre for Advanced Medical Imaging (CAMI), St. James's Hospital, Dublin, Ireland., Kelly ME; Department of Radiology, St. James's Hospital, Dublin, Ireland.; Department of Surgery, St. James's Hospital, Dublin, Ireland.
Jazyk: angličtina
Zdroj: Abdominal radiology (New York) [Abdom Radiol (NY)] 2024 Oct; Vol. 49 (10), pp. 3540-3547. Date of Electronic Publication: 2024 May 15.
DOI: 10.1007/s00261-024-04330-8
Abstrakt: Ovarian cancer is associated with high cancer-related mortality rate attributed to late-stage diagnosis, limited treatment options, and frequent disease recurrence. As a result, careful patient selection is important especially in setting of radical surgery. Radiomics is an emerging field in medical imaging, which may help provide vital prognostic evaluation and help patient selection for radical treatment strategies. This systematic review aims to assess the role of radiomics as a predictor of disease recurrence in ovarian cancer. A systematic search was conducted in Medline, EMBASE, and Web of Science databases. Studies meeting inclusion criteria investigating the use of radiomics to predict post-operative recurrence in ovarian cancer were included in our qualitative analysis. Study quality was assessed using the QUADAS-2 and Radiomics Quality Score tools. Six retrospective studies met the inclusion criteria, involving a total of 952 participants. Radiomic-based signatures demonstrated consistent performance in predicting disease recurrence, as evidenced by satisfactory area under the receiver operating characteristic curve values (AUC range 0.77-0.89). Radiomic-based signatures appear to good prognosticators of disease recurrence in ovarian cancer as estimated by AUC. The reviewed studies consistently reported the potential of radiomic features to enhance risk stratification and personalise treatment decisions in this complex cohort of patients. Further research is warranted to address limitations related to feature reliability, workflow heterogeneity, and the need for prospective validation studies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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