Prevalence of the cagA Virulence Factor Varies by Race Among Helicobacter pylori -Infected Patients Undergoing Upper Endoscopy.

Autor:	Epplein M; Cancer Risk, Detection, and Interception Program, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Population Health Sciences, Duke University, Durham, North Carolina, USA., McCall SJ; Department of Pathology, Duke University, Durham, North Carolina, USA., Wang F; Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, USA., Alagesan P; School of Medicine, Duke University, Durham, North Carolina, USA., Brown H; Department of Medicine, Duke University, Durham, North Carolina, USA., Wawrzynski J; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA., Labriola C; School of Medicine, Duke University, Durham, North Carolina, USA., Zuzul R; School of Medicine, Duke University, Durham, North Carolina, USA., Cook C; School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Dillon M; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Hyslop T; Cancer Risk, Detection, and Interception Program, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Biostatistics & Bioinformatics, Duke University, Durham, North Carolina, USA.; Division of Biostatistics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Patierno SR; Cancer Risk, Detection, and Interception Program, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Medicine, Duke University, Durham, North Carolina, USA., Salama NR; Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Garman KS; Cancer Risk, Detection, and Interception Program, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Medicine, Duke University, Durham, North Carolina, USA.; Division of Gastroenterology, Department of Medicine, Duke University, Durham, North Carolina, USA.
Jazyk:	angličtina
Zdroj:	Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2024 Jun 01; Vol. 15 (6), pp. e1. Date of Electronic Publication: 2024 Jun 01.
DOI:	10.14309/ctg.0000000000000713
Abstrakt:	Introduction: We designed a race-conscious study to assess the presence of Helicobacter pylori v irulence factor cagA in a retrospective cohort of patients with active H. pylori infection. Methods: We compared cagA status by race in gastric tissue samples from 473 patients diagnosed with active H. pylori infection from 2015 to 2019. Results: H. pylori + Black patients were 2 times more likely to be cagA + than H. pylori + White patients (82% vs 36%, P < .0001). Discussion: Presence of cagA is common among endoscopy patients with active H. pylori infection; appropriate testing and treatment of H. pylori can both reduce gastric cancer risk and address health disparities. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
Databáze:	MEDLINE
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