Highly Effective Pyroelectric Catalysis for Simultaneous Tumor-Targeted Dynamic Therapy and Gentle Photothermal Therapy by Oxygen-Vacancy-Rich CeO 2 -BaTiO 3 Nanorods.

Autor: Chen Y; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Wang Y; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Shi J; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Guo C; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Qi L; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Zhao J; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Luo S; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Zhou H; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China., Lu X; Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies), Nanjing Tech University, 30 South Puzhu Road, Nanjing, 211816, China.; Zhengzhou Institute of Biomedical Engineering and Technology, Zhengzhou, 450001, China., Fan Q; Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Post & Telecommunications, Nanjing, 210021, China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (23), pp. e2400781. Date of Electronic Publication: 2024 Jun 28.
DOI: 10.1002/adhm.202400781
Abstrakt: Pyroelectric nanostructures can effectively generate temperature-mediated reactive oxygen species (ROS) through the pyroelectric effect, providing promise for treating hypoxic tumors; and therefore, the synergistic application of photothermal therapy (PTT) and pyroelectric dynamic therapy (PEDT) presents an intriguing approach for cancer therapy. However, this method still faces challenges in improving pyroelectric catalysis and achieving precise tumor localization. In this study, a nano-heterojunction based on CeO 2 -BaTiO 3 nanorods (IR1061@PCBNR) is reported, which exhibits highly effective pyroelectric catalysis for simultaneous tumor-targeted dynamic therapy and gentle photothermal therapy through the utilization of the rich oxygen vacancies. The oxygen vacancies create active sites that facilitate the migration of pyroelectrically-induced charge carriers, improving charge separation and ROS generation. IR1061@PCBNR also demonstrates high tumor penetration; while, minimizing damage to normal cells. This precise nanomedicine strategy holds great potential for advancing dynamic cancer therapies by overcoming the limitations of conventional approaches.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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