A Pseudo-Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics.

Autor: Liu SS; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.; Meinig School of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY, 14850, USA., White JM; Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA., Chao Z; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Li R; Department of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY, 14850, USA., Wen S; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Garza A; Department of Health and Biomedical Sciences, University of Texas Rio Grande Valley 1201 W University Drive, Edinburg, TX, 78539, USA., Tang W; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Ma X; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Chen P; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Daniel S; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA., Bates FS; Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA., Yeo J; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Upson Hall, Ithaca, NY, 14850, USA., Calabrese MA; Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA., Yang R; Robert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (22), pp. e2400457. Date of Electronic Publication: 2024 May 21.
DOI: 10.1002/adhm.202400457
Abstrakt: Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin-like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, can compromise gelation, formulation stability, and drug diffusion. To overcome this challenge, differing interactions between CPEs and the hydrogel system are explored, especially those with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and those with methyl laurate (ML), a nonionic counterpart with a similar length alkyl chain. Notably, the use of ML effectively decouples permeation enhancement from gelation, enabling sustained delivery across TMs to treat acute otitis media (AOM), which is not possible with the use of SDS. Ciprofloxacin and ML are shown to form a pseudo-surfactant that significantly boosts transtympanic permeation. The middle ear ciprofloxacin concentration is increased by 70-fold in vivo in a chinchilla AOM model, yielding superior efficacy and biocompatibility than the previous highest-performing formulation. Beyond improved efficacy and biocompatibility, this single-CPE formulation significantly accelerates its progression toward clinical deployment.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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