NTRK gene fusion testing and management in lung cancer.

Autor: Repetto M; Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA. Electronic address: repettom@mskcc.org., Chiara Garassino M; Department of Medicine, Thoracic Oncology Program, The University of Chicago, Chicago, IL, USA., Loong HH; The Chinese University of Hong Kong, Hong Kong, China., Lopez-Rios F; Hospital Universitario 12 de Octubre, Madrid, Spain., Mok T; The Chinese University of Hong Kong, Hong Kong, China., Peters S; Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland., Planchard D; Gustave Roussy, Villejuif, France., Popat S; Royal Marsden NHS Foundation Trust, London, UK; Institute of Cancer Research, London, UK., Rudzinski ER; Seattle Children's Hospital and University of Washington Medical Center, Seattle, WA, USA., Drilon A; Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA., Zhou C; Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.
Jazyk: angličtina
Zdroj: Cancer treatment reviews [Cancer Treat Rev] 2024 Jun; Vol. 127, pp. 102733. Date of Electronic Publication: 2024 Apr 03.
DOI: 10.1016/j.ctrv.2024.102733
Abstrakt: Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are recurrent oncogenic drivers found in a variety of solid tumours, including lung cancer. Several tropomyosin receptor kinase (TRK) inhibitors have been developed to treat tumours with NTRK gene fusions. Larotrectinib and entrectinib are first-generation TRK inhibitors that have demonstrated efficacy in patients with TRK fusion lung cancers. Genomic testing is recommended for all patients with metastatic non-small cell lung cancer for optimal drug therapy selection. Multiple testing methods can be employed to identify NTRK gene fusions in the clinic and each has its own advantages and limitations. Among these assays, RNA-based next-generation sequencing (NGS) can be considered a gold standard for detecting NTRK gene fusions; however, several alternatives with minimally acceptable sensitivity and specificity are also available in areas where widespread access to NGS is unfeasible. This review highlights the importance of testing for NTRK gene fusions in lung cancer, ideally using the gold-standard method of RNA-based NGS, the various assays that are available, and treatment algorithms for patients.
Competing Interests: Declaration of competing interest Support for attending meetings and/or travel: Sanofi. Marina Chiara Garassino: Personal financial interests: AstraZeneca, Abion, MSD International GmbH, Bayer, BMS, Boehringer Ingelheim Italia S.p.A, Celgene, Eli Lilly, Incyte, Novartis, Pfizer, Roche, Takeda, Seattle Genetics, Mirati, Daiichi Sankyo, Regeneron, Merck, Blueprint, Jansenn, Sanofi, AbbVie, BeiGenius, Oncohost, Medscape, Gilead, Io Biotech; Institutional financial interests: Eli Lilly, MSD, Pfizer (MISP); AstraZeneca, MSD International GmbH, BMS, Boehringer Ingelheim Italia S.p.A, Celgene, Eli Lilly, Ignyta, Incyte, MedImmune, Novartis, Pfizer, Roche, Takeda, Tiziana, Foundation Medicine, GSK, Spectrum Pharmaceuticals; Others: AIRC, AIFA, Italian Moh, TRANSCAN; Research funding, Horizon 2020. Herbert H. Loong: Advisory: Boehringer Ingelheim, Celgene, Daiichi Sankyo, Eli Lilly, Illumina, Novartis, Merck Sereno, Takeda, George Clinical; Speakers’ bureau: AbbVie, Bayer, Daiichi Sankyo, Eisai, Eli Lilly, Guardant Health, Novartis; Travel support: Bayer, Boehringer Ingelheim, MSD, Novartis, Pfizer; Research funding: MSD, Mundipharma, Novartis; Others: Member of Pharmacy and Poisons (Registration of Pharmaceutical Products and Substances: Certification of Clinical Trial/Medicinal Test) Committee, Pharmacy & Poisons Board of Hong Kong. Fernando Lopez-Rios: Honoraria/advisory boards: Abbvie, Astellas, AstraZeneca, Bayer, BMS, Daiichi Sankyo, Janssen, Lilly, MSD, Merck, Pfizer, Roche, Sanofi, Takeda, Thermo Fisher Scientific; Associated research paid to institution: AstraZeneca, Lilly, Pfizer, Roche, Thermo Fisher Scientific. Tony Mok: Grant/research support from (paid to institution): AstraZeneca, BMS, G1 Therapeutics, MSD, Merck Serono, Novartis, Pfizer, Roche, SFJ, Takeda, XCovery; Speaker’s fees received from: ACEA Pharma, Alpha Biopharma Co., Ltd., Amgen, Amoy Diagnostics Co., Ltd., AstraZeneca (before 1/1/19), BeiGene, Boehringer Ingelheim, BMS, Daiichi Sankyo, Daz Group, Fishawack Facilitate Ltd., InMed Medical Communication, Janssen Pharmaceutica NV, Jiahui Holdings Co. Limited, LiangYiHui Healthcare, Lilly, Lucence Health Inc., MD Health Brazil, Medscape LLC, Merck Pharmaceuticals HK Ltd., Merck Sharp & Dohme, MiRXES, Novartis, OrigiMed Co. Ltd., P. Permanyer SL, PeerVoice, Physicians’ Education Resource (PER), Pfizer, PrIME Oncology, Research to Practice, Roche Pharmaceuticals/Diagnostics/Foundation One, Sanofi-Aventis, Shanghai BeBirds Translation & Consulting Co., Ltd., Shanghai Promedican Pharmaceuticals Co., Ltd., Taiho Pharmaceutical Co. Ltd, Takeda Oncology, Touch Independent Medical Education Ltd; Honoraria/honorarium received (for consultation services/as independent consultant) from: Abbvie Inc., ACEA Pharma, Adagene, Alpha Biopharma Co., Ltd., Amgen, Amoy Diagnostics Co., Ltd., AnHeart Therapeutics, AstraZeneca (before 1/1/19), AVEO Pharmaceuticals, Inc., Bayer Healthcare Pharmaceuticals Ltd., BeiGene, BerGenBio ASA, Berry Oncology, Boehringer Ingelheim, Blueprint Medicines Corporation, BMS, Bowtie Life Insurance Company Limited, Bridge Biotherapeutics Inc., Covidien LP, C4 Therapeutics Inc., Cirina Ltd., CStone Pharmaceuticals, Curio Science, D3 Bio Ltd., Da Volterra, Daiichi Sankyo, Eisai, Elevation Oncology, F. Hoffmann-La Roche Ltd., Genentech, GLG’s Healthcare, Fishawack Facilitate Ltd., G1 Therapeutics Inc., geneDecode Co., Ltd, Gilead Sciences, Inc. Gritstone Oncology, Inc., Guardant Health, Hengrui Therapeutics Inc., HutchMed, Ignyta, Inc., Illumina, Inc., Incyte Corporation, Inivata, IQVIA, Janssen, Lakeshore Biotech Ltd, Lilly, Lunit USA, Inc., Loxo Oncology, Lucence Health Inc., Medscape LLC/ WebMD, Medtronic, Merck Serono, MSD, Mirati Therapeutics Inc., MiRXES, MoreHealth, Novartis, Novocure GmbH, Omega Therapeutics Inc., OrigiMed, OSE Immunotherapeutics, PeerVoice, Pfizer, PrIME Oncology, Prenetics, Puma Biotechnology Inc., Qiming Development (HK) Ltd., Regeneron Pharmaceuticals Inc., Roche Pharmaceuticals/Diagnostics/Foundation One, Sanofi-Aventis, SFJ Pharmaceutical Ltd., Simcere of America Inc., Summit Therapeutics Sub, Inc., Synergy Research, Takeda Pharmaceuticals HK Ltd., Tigermed, Vertex Pharmaceuticals, Virtus Medical Group, XENCOR, Inc., Yuhan Corporation; Stock shareholder in: Alentis Therapeutics AG, AstraZeneca, Aurora Tele-Oncology Ltd., Biolidics Ltd., HutchMed, Prenetics, D3 Bio, Lunit Inc.; Stock options: Bowtie Life Insurance Co. Ltd., D3 Bio, Lakeshore Biotech Ltd, Loxo Oncology, Lunit USA, Inc., Virtus Medical Group, Phanes Therapeutics, Inc., Insighta; Advisory board for: AbbVie Inc., ACEA Pharma, Amgen, AstraZeneca, BerGenBio ASA, Berry Oncology, Blueprint Medicines Corporation, Boehringer Ingelheim, Bowtie Life Insurance Co Ltd, BMS, C4 Therapeutics Inc, Covidien LP, CStone Pharmaceuticals, Curio Science, D3 Bio Ltd., Daiichi Sankyo Inc., Eisai, Fishawack Facilitate Ltd., G1 Therapeutics Inc., Gilead Sciences Inc., Gritstone Oncology, Inc., Guardant Health, geneDecode Co. Ltd. (uncompensated), Hengrui Therapeutics Inc., HutchMed, Ignyta Inc., Incyte Corporation, Imagene AI Ltd., Inivata, IQVIA, Janssen, Lakeshore Biotech, Lily, Loxo Oncology Inc., Lunit, Inc., Merck Serono, Merck Sharp & Dohme, Mirati Therapeutics Inc., MiRXES Group, Novartis, OrigiMed, Pfizer, Prenetics, Puma Biotechnology Inc., Roche/Genentech, Regeneron Pharmaceuticals Inc., Sanofi-Aventis R&D, SFJ Pharmaceutical, Simcere of America Inc., Simcere Zaiming, Inc., Takeda, Vertex Pharmaceuticals, Virtus Medical Group, Yuhan Corporation; Board of directors/leadership roles (remunerated): AstraZeneca PLC (from January 2019–Present), HutchMed, Aurora, Insighta (from July 2023–Present); Board of directors/leadership roles (non-remunerated): American Society of Clinical Oncology (2018–2022), Asian Thoracic Oncology Research Group (2016–Present), Chinese Lung Cancer Research Foundation Limited (2005–2012), Chinese Society of Clinical Oncology (2009–2020), Hong Kong Cancer Fund (2011–Present), Hong Kong Cancer Therapy Society (2004–Present), International Association for the Study of Lung Cancer (2007–2019), St. Stephen’s College & Prep. School (2017–Present), Hong Kong Academy of Sciences (2022–Present). Solange Peters: I have Received education grants, provided consultation, attended advisory boards and/or provided lectures for the following organizations, from whom honoraria received (all fees to institution): Consultation/Advisory role: AbbVie, Amgen, Arcus, AstraZeneca, Bayer, Beigene, BerGenBio, Biocartis, BioInvent, Blueprint Medicines, Boehringer Ingelheim, BMS, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F-Star, Fishawack, Foundation Medicine, Genzyme, Gilead, GSK, Hutchmed, Illumina, Incyte, Ipsen, iTeos, Janssen, Merck Sharp and Dohme, Merck Serono, Merrimack, Mirati, Nykode Therapeutics, Novartis, Novocure, Pharma Mar, Promontory Therapeutics, Pfizer, Regeneron, Roche/Genentech, Sanofi, Seattle Genetics, Takeda; Board of director position: Galenica; Talk in a company’s organized public event: AstraZeneca, Boehringer Ingelheim, BMS, Eli Lilly, Foundation Medicine, GSK, Illumina, Ipsen, Merck Sharp and Dohme, Mirati, Novartis, Pfizer, Roche/Genentech, Sanofi, Takeda; Receipt of grants/research supports: Principal investigator in trials (institutional financial support for clinical trials) sponsored by: Amgen, Arcus, AstraZeneca, Beigene, BMS, GSK, iTeos, Merck Sharp and Dohme, Mirati, Pharma Mar, Promontory Therapeutics, Roche/Genentech, Seattle Genetics. David Planchard: Consulting, advisory role or lectures: AstraZeneca, Abbvie, BMS, Boehringer Ingelheim, Celgene, Daiichi Sankyo, Eli Lilly, Merck, Novartis, Janssen, Pfizer, Roche, Pierre-fabre, Takeda, ArriVent, Mirati, Seagen; Clinical trials research as principal or co-investigator (institutional financial interests): AstraZeneca, BMS, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Pfizer, Roche, Medimmune, Sanofi-Aventis, Taiho Pharma, Novocure, Daiichi Sankyo, Abbvie, Janssen, Pierre-Fabre, Takeda, ArriVent, Mirati, Seagen; Travel, accommodations and/or expenses: AstraZeneca, Roche, Novartis, Pfizer. Sanjay Popat: Consulting fees (personal fees): Amgen, AstraZeneca, Bayer, Blueprint, BMS, Boehringer Ingelheim, Daiichi Sankyo, GSK, Guardant Health, Incyte, Janssen, Lilly, Merck Serono, MSD, Novartis, Roche, Takeda, Pfizer, Seattle Genetics, Turning Point Therapeutics, EQRx; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events (personal fees): AstraZeneca, Bayer, Guardant Health, Janssen, Merck Serono, Roche, Takeda; Payment for expert testimony (personal fees): Roche, Merck Serono; Support for attending meetings and/or travel (travel expenses reimbursement): Janssen, Roche; Leadership in fiduciary role in other board, society, committee or advocacy group (unpaid): British Thoracic Oncology Group, ALK Positive UK, Lung Cancer Europe, Ruth Strauss Foundation, Mesothelioma Applied Research Foundation; ETOP-IBCSG Partners Foundation Board. Erin R. Rudzinski: Clinical trials research: ON-TRK study (Bayer). Alexander Drilon: Honoraria/advisory boards: 14ner/Elevation Oncology, Amgen, Abbvie, ArcherDX, AstraZeneca, Beigene, BergenBio, Blueprint Medicines, Chugai Pharmaceutical, EcoR1, EMD Serono, Entos, Exelixis, Helsinn, Hengrui Therapeutics, Ignyta/Genentech/Roche, Janssen, Loxo/Bayer/Lilly, Merus, Monopteros, MonteRosa, Novartis, Nuvalent, Pfizer, Prelude, Repare RX, Takeda/Ariad/Millenium, Treeline Bio, TP Therapeutics, Tyra Biosciences, Verastem; Associated research paid to institution: Pfizer, Exelixis, GSK, Teva, Taiho, PharmaMar; Royalties: Wolters Kluwer; Other (food/beverage): Merck, Puma, Merus, Boehringer Ingelheim; CME honoraria: Answers in CME, Applied Pharmaceutical Science, Inc., AXIS, Clinical Care Options, EPG Health, Harborside Nexus, I3 Health, Imedex, Liberum, Medendi, Medscape, Med Learning, MJH Life Sciences, MORE Health, Ology, OncLive, Paradigm, Peerview Institute, PeerVoice, Physicians Education Resources, Remedica Ltd., Research to Practice, RV More, Targeted Oncology, TouchIME, WebMD. Caicun Zhou: Consulting fees: Innovent Biologics, Hengrui, Qilu, TopAlliance Biosciences; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events: Lily China, Sanofi, Boehringer Ingelheim, Roche, Merck Sharp & Dohme, Qilu, Hengrui, Innovent Biologics, Alice, C-Stone, LUYE Pharma, TopAlliance Biosciences, Amoy Diagnostics, AnHeart.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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