Correlation of Non-Invasive Transthoracic Doppler Echocardiography with Invasive Doppler Wire-Derived Coronary Flow Reserve and Their Impact on Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention.

Autor: Milasinovic D; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Tesic M; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Nedeljkovic Arsenovic O; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Center for Radiology and Magnetic Resonance, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Maksimovic R; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Center for Radiology and Magnetic Resonance, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Sobic Saranovic D; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.; Center for Nuclear Medicine with PET, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Jelic D; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Zivkovic M; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Dedovic V; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Juricic S; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Mehmedbegovic Z; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Petrovic O; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Trifunovic Zamaklar D; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Djordjevic Dikic A; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Giga V; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Boskovic N; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Klaric M; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Zaharijev S; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Travica L; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Dukic D; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Mladenovic D; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia., Asanin M; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia., Stankovic G; Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Apr 24; Vol. 13 (9). Date of Electronic Publication: 2024 Apr 24.
DOI: 10.3390/jcm13092484
Abstrakt: Background : Coronary microvascular dysfunction is associated with adverse prognosis after ST-segment elevation myocardial infarction (STEMI). We aimed to compare the invasive, Doppler wire-based coronary flow reserve (CFR) with the non-invasive transthoracic Doppler echocardiography (TTDE)-derived CFR, and their ability to predict infarct size. Methods : We included 36 patients with invasive Doppler wire assessment on days 3-7 after STEMI treated with primary percutaneous coronary intervention (PCI), of which TTDE-derived CFR was measured in 47 vessels (29 patients) within 6 h of the invasive Doppler. Infarct size was assessed by cardiac magnetic resonance at a median of 8 months. Results : The correlation between invasive and non-invasive CFR was modest in the overall cohort (rho 0.400, p = 0.005). It improved when only measurements in the LAD artery were considered (rho 0.554, p = 0.002), with no significant correlation in the RCA artery (rho -0.190, p = 0.435). Both invasive (AUC 0.888) and non-invasive (AUC 0.868) CFR, measured in the recanalized culprit artery, showed a good ability to predict infarct sizes ≥18% of the left ventricular mass, with the optimal cut off values of 1.85 and 1.80, respectively. Conclusions : In patients with STEMI, TTDE- and Doppler wire-derived CFR exhibit significant correlation, when measured in the LAD artery, and both have a similarly strong association with the final infarct size.
Databáze: MEDLINE
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