Early Liver Transplant for Alcohol-associated Liver Disease Has Excellent Survival but Higher Rates of Harmful Alcohol Use.

Autor:	Musto JA; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: jamusto@medicine.wisc.edu., Palmer G; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Nemer M; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Schell T; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Waclawik G; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Glover Q; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Lucey MR; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Osman F; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin., Rice JP; University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Jazyk:	angličtina
Zdroj:	Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2024 Aug; Vol. 22 (8), pp. 1646-1656.e2. Date of Electronic Publication: 2024 May 08.
DOI:	10.1016/j.cgh.2024.04.025
Abstrakt:	Background & Aims: Early liver transplantation (LT) for alcohol-associated liver disease (ALD) has increased worldwide. Short-term outcomes have been favorable, but data on longer-term outcomes are lacking. Methods: Single-center retrospective study of primary LT recipients between 2010 and 2020, with follow-up through July 1, 2022. Survival analysis was performed using log rank, Cox models, and Kaplan-Meier method. Cox models were created to identify variables associated with mortality; logistic regression to identify variables associated with post-LT alcohol use. Results: Of 708 patients who underwent LT, 110 (15.5%) had ALD and abstinence <6 months prior to LT (ELT), 234 (33.1%) had ALD and alcohol abstinence >6 months (SLT), and 364 (51.4%) had non-ALD diagnoses. Median follow-up was 4.6 years (interquartile range, 2.6-7.3 years). ELT recipients were younger (P = .001) with median abstinence pre-LT of 61.5 days. On adjusted Cox model, post-LT survival was similar in ELT and SLT (hazard ratio [HR], 1.31; P = .30) and superior to non-ALD (HR, 1.68; P = .04). Alcohol use (40.9% vs 21.8%; P < .001) and harmful alcohol use (31.2% vs 16.0%; P = .002) were more common in ELT recipients. Harmful alcohol use was associated with post-LT mortality on univariate (HR, 1.69; P = .03), but not multivariable regression (HR, 1.54; P = .10). Recurrence of decompensated ALD trended toward more common in ELT (9.1% vs 4.4%; P = .09). Greater than 6 months pre-LT abstinence was associated with a decreased risk of harmful alcohol use (odds ratio, 0.42; P = .001), but not in a multivariable model (odds ratio, 0.71; P = .33). Conclusions: Patients who undergo ELT for ALD have similar or better survival than other diagnoses in the first 10 years after LT despite a higher incidence of post-LT alcohol use. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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