Quality of Life in Transfusion-Dependent Thalassemia Patients in Greece Before and During the COVID-19 Pandemic.

Autor: Klonizakis P; Adults Thalassemia Unit-2nd Department of Internal Medicine, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece. Electronic address: philklon@gmail.com., Klaassen RJ; Department of Pediatrics, Division of Hematology/Oncology, University of Ottawa, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada., Roy N; Department of Haematology, Oxford University Hospitals, NHS Foundation Trust, Oxford, England, UK., Papatsouma I; Department of Mathematics, Imperial College, London, England, UK., Mainou M; Adults Thalassemia Unit-2nd Department of Internal Medicine, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece., Christodoulou I; Adults Thalassemia Unit-2nd Department of Internal Medicine, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece., Tsapas A; 2nd Department of Internal Medicine, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece., Vlachaki E; Adults Thalassemia Unit-2nd Department of Internal Medicine, Aristotle University, Hippokration General Hospital, Thessaloniki, Greece.
Jazyk: angličtina
Zdroj: Value in health regional issues [Value Health Reg Issues] 2024 Jul; Vol. 42, pp. 100986. Date of Electronic Publication: 2024 May 08.
DOI: 10.1016/j.vhri.2024.100986
Abstrakt: Objectives: The peak of the COVID-19 pandemic was a challenging situation for transfusion-dependent thalassemia (TDT) patients. The objectives of this study were to measure the quality of life (QoL) in TDT patients during the COVID-19 lockdown restriction measures, compare the results with the pre-COVID-19 era, and evaluate the influence of sociodemographic and clinical factors on QoL.
Methods: This was a cross-sectional study of 110 consecutively selected adult TDT patients, during the stringent lockdown restriction measures implemented in Greece. All participants completed a combination of 2 QoL questionnaires, the generic Short-Form Health Survey 36 version 2 and the disease-specific Transfusion-Quality of life (TranQol). We used the "1/2 SD method," a distribution-based approach to calculate minimal clinically important differences and clinically compare the QoL scores between the pre-COVID-19 and post-COVID-19 era. A backward stepwise linear regression was selected to explore the influence of potential predictors on TranQol scores.
Results: The Short-Form Health Survey 36 version 2 and TranQol scores remained low but not clinically different compared with the pre-COVID-19 era. Older, married, and higher educated TDT patients exhibited significantly lower TranQol summary scores. The patients who reported a negative effect of the COVID-19 pandemic had significantly lower TranQol scores in summary and all subdomains except for school and career.
Conclusions: During the COVID-19 pandemic, the overall QoL of TDT patients was clinically similar to the status of the pre-COVID-19 era. Nevertheless, most of the significant QoL subdomains were negatively affected, and distinct groups of TDT patients were more vulnerable.
Competing Interests: Author Disclosures Author disclosure forms can be accessed below in the Supplemental Material section.
(Copyright © 2024 International Society for Health Economics and Outcomes Research. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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