Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.

Autor:	Zaffaroni G; Center for Hereditary Tumors, Bethesda Hospital, Duisburg, Germany.; Faculty of Medicine and Surgery, University of Milan, Milan, Italy., Mannucci A; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy., Koskenvuo L; Department of Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., de Lacy B; Department of Gastrointestinal Surgery, Hospital Clinic of Barcelona, Barcelona, Spain., Maffioli A; Faculty of Medicine and Surgery, University of Milan, Milan, Italy.; Department of General Surgery, Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy., Bisseling T; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands., Half E; Cancer Prevention and Hereditary GI Cancer Unit, Rambam Health Care Campus, Haifa, Israel., Cavestro GM; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy., Valle L; Hereditary Cancer Program, Catalan Institute of Oncology, Oncobell Program, IDIBELL, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Ryan N; The College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK., Aretz S; Institute of Human, Genetics, Medical Faculty, University of Bonn and National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany., Brown K; Leicester Cancer Research Centre, University of Leicester, Leicester, UK., Buttitta F; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; IRCCS University Hospital of Bologna, Policlinico di Sant'Orsola, Bologna, Italy., Carneiro F; Faculty of Medicine of Porto University, Centro Hospitalar Universitário de São João, Ipatimup, Porto, Portugal., Claber O; Department of Clinical Genetics, Northern Genetics Service, Newcastle upon Tyne, UK., Blanco-Colino R; Department of Gastrointestinal Surgery, Vall d'Hebron University Hospital, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain., Collard M; Department of Digestive Surgery, Hôpital Saint-Antoine, Sorbonne University, APHP, Paris, France., Crosbie E; Division of Cancer Sciences, University of Manchester, Manchester, UK., Cunha M; Department of Surgery, Algarve Universitary Hospital Center, Colorectal SurgeryGroup, Portimao, Portugal., Doulias T; Department of Colorectal Surgery, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Colchester, UK.; Colorectal Surgery Department, Kettering Hospital, University Hospitals of Northamptonshire, Kettering, Northamptonshire, UK.; Department of Genetics and Genome Biology, Honorary Lecturer in the Leicester Cancer Research Centre, Leicester, UK., Fleming C; Department of Colorectal Surgery, University Hospital Limerick, Limerick, Ireland., Heinrich H; Department for Gastroenterology and Hepatology, Clarunis Universitäres Bauchzentrum, Universitätsspital Basel, Basel, Switzerland., Hüneburg R; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.; National Center for Hereditary Tumour Syndromes, University Hospital Bonn, Bonn, Germany., Metras J; Department of Digestive Surgery, Hôpital Saint-Antoine, Sorbonne University, APHP, Paris, France., Nagtegaal I; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Negoi I; Department of General Surgery, Carol Davila University of Medicine and Pharmacy Bucharest, Emergency Hospital of Bucharest, Bucharest, Romania., Nielsen M; Clinical Genetics Department, Leiden University Medical Center, Leiden, The Netherlands., Pellino G; Department of Gastrointestinal Surgery, Vall d'Hebron University Hospital, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Ricciardiello L; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.; IRCCS University Hospital of Bologna, Policlinico di Sant'Orsola, Bologna, Italy., Sagir A; Center for Hereditary Tumors, Bethesda Hospital, Duisburg, Germany., Sánchez-Guillén L; Department of Gastrointestinal Surgery, Elche General University Hospital, Elche, Alicante, Spain.; Miguel Hernández University, Elche, Spain., Seppälä TT; Department of Gastroenterological Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland.; Faculty of Medicine and Health Technology, University of Tampere and TAYS Cancer Centre, Tampere, Finland.; iCAN Precision Medicine Flagship, University of Helsinki, Helsinki, Finland., Siersema P; Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands., Striebeck B; Support Group Polyposis Coli e.V., FAP Patient, Germany., Sampson JR; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Latchford A; Polyposis Registry, St Mark's Hospital, Harrow, UK.; Department of Surgery and Cancer, Imperial College, London, UK., Parc Y; Department of Digestive Surgery, Hôpital Saint-Antoine, Sorbonne University, APHP, Paris, France., Burn J; Newcastle University Translational and Clinical Research Institute, Centre for Life, Newcastle upon Tyne, UK., Möslein G; Center for Hereditary Tumors, Bethesda Hospital, Duisburg, Germany.
Jazyk:	angličtina
Zdroj:	The British journal of surgery [Br J Surg] 2024 May 03; Vol. 111 (5).
DOI:	10.1093/bjs/znae070
Abstrakt:	Background: Hereditary adenomatous polyposis syndromes, including familial adenomatous polyposis and other rare adenomatous polyposis syndromes, increase the lifetime risk of colorectal and other cancers. Methods: A team of 38 experts convened to update the 2008 European recommendations for the clinical management of patients with adenomatous polyposis syndromes. Additionally, other rare monogenic adenomatous polyposis syndromes were reviewed and added. Eighty-nine clinically relevant questions were answered after a systematic review of the existing literature with grading of the evidence according to Grading of Recommendations, Assessment, Development, and Evaluation methodology. Two levels of consensus were identified: consensus threshold (≥67% of voting guideline committee members voting either 'Strongly agree' or 'Agree' during the Delphi rounds) and high threshold (consensus ≥ 80%). Results: One hundred and forty statements reached a high level of consensus concerning the management of hereditary adenomatous polyposis syndromes. Conclusion: These updated guidelines provide current, comprehensive, and evidence-based practical recommendations for the management of surveillance and treatment of familial adenomatous polyposis patients, encompassing additionally MUTYH-associated polyposis, gastric adenocarcinoma and proximal polyposis of the stomach and other recently identified polyposis syndromes based on pathogenic variants in other genes than APC or MUTYH. Due to the rarity of these diseases, patients should be managed at specialized centres. (© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd.)
Databáze:	MEDLINE
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