| Autor: |
Katz BR; Department of Psychiatry, University of Vermont., Gaalema DE; Department of Psychiatry, University of Vermont., Dumas JA; Department of Psychiatry, University of Vermont., Heil SH; Department of Psychiatry, University of Vermont., Sigmon SC; Department of Psychiatry, University of Vermont., Tidey JW; Center for Alcohol and Addiction Studies, Brown University., Lee DC; Behavioral Pharmacology Research Unit, Johns Hopkins University., DeSarno M; Department of Medical Biostatistics, University of Vermont., Higgins ST; Department of Psychiatry, University of Vermont. |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and clinical psychopharmacology [Exp Clin Psychopharmacol] 2024 Aug; Vol. 32 (4), pp. 436-444. Date of Electronic Publication: 2024 May 09. |
| DOI: |
10.1037/pha0000724 |
| Abstrakt: |
Reductions in the nicotine content of cigarettes decrease smoking rate and dependence severity, but effects on cognition are less well established. The potential impacts of very-low nicotine-content (VLNC) cigarettes on cognitive task performance must be evaluated, especially in vulnerable populations. The aim of the present study is to experimentally examine the effects of VLNC cigarettes on cognitive performance. Adults who smoked daily ( n = 775) from three vulnerable populations (socioeconomically disadvantaged reproductive-age women, individuals with opioid use disorder, affective disorders) were examined. Participants were randomly assigned to normal nicotine content (NNC; 15.8 mg nicotine/g tobacco) or VLNC (2.4 mg/g or 0.4 mg/g) cigarettes for 12 weeks. Response inhibition (stop-signal task), working memory ( n -back task; n of 2- n of 0), and cognitive interference (nicotine Stroop task) were assessed at baseline, 2, 6, and 12 weeks. Results were analyzed using mixed-model repeated-measures analyses of variance. Extended exposure to VLNC cigarettes produced no significant changes in any measure of cognitive performance compared to NNC cigarettes. Over weeks, response times on the n -back task decreased across doses. No significant effects were observed on the stop-signal or nicotine Stroop tasks. All three vulnerable populations performed comparably on all three cognitive tasks. Extended exposure to VLNC cigarettes produced no impairments in cognitive performance on any of the assessed tasks compared to NNC cigarettes. These findings are consistent with the larger literature detailing other consequences following exposure to VLNC cigarettes and are encouraging for the adoption of a nicotine-reduction policy. (PsycInfo Database Record (c) 2024 APA, all rights reserved). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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