Normal pressure hydrocephalus and cognitive impairment: The gait phenotype matters too.

Autor: Morel E; Department of Neurology, University Clinic of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Leenaards Memory Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Lingenberg A; Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland., Armand S; Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Willy Taillard Laboratory of Kinesiology, Geneva University Hospitals, Geneva, Switzerland., Assal F; Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland., Allali G; Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Leenaards Memory Centre, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.; Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York, USA.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2024 Aug; Vol. 31 (8), pp. e16328. Date of Electronic Publication: 2024 May 08.
DOI: 10.1111/ene.16328
Abstrakt: Background and Purpose: Idiopathic normal pressure hydrocephalus (iNPH) is a chronic neurological disease resulting in progressive gait and cognitive disorders. We investigated whether the gait phenotype is associated with the severity of cognitive deficits in iNPH.
Methods: This retrospective study recruited 88 patients (mean age = 76.18 ± 7.21 years, 42% female). Patients were initially referred for suspicion of iNPH and underwent a comprehensive analysis, including gait analysis and cognitive evaluation.
Results: In this cohort (27% normal gait, 25% frontal gait, 16% parkinsonian gait, 27% other gait abnormalities), patients with parkinsonian and frontal gait had the lowest Mini-Mental State Examination (MMSE) scores and the slowest gait speed. Patients with normal gait had the highest MMSE scores and gait speed. Frontal gait was associated with lower MMSE score, even after adjusting for age, gender, comorbidities, white matter lesions, and education level (β = -0.221 [95% confidence interval (CI) = -3.718 to -0.150], p = 0.034). Normal gait was associated with the best MMSE scores, even after adjusting for the abovementioned variables (β = 0.231 [95% CI = 0.124-3.639], p = 0.036).
Conclusions: Gait phenotypes among iNPH patients are linked to global cognition as assessed with MMSE.
(© 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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