The gut microbiome in alcohol use disorder and alcohol-associated liver disease: A systematic review of clinical studies.

Autor:	Grodin EN; Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.; Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA., Burnette EM; Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA., Rodriguez C; Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA., Fulcher JA; Division of Infectious Diseases, David Gefen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA., Ray LA; Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.; Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA.
Jazyk:	angličtina
Zdroj:	Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2024 Jul; Vol. 48 (7), pp. 1221-1242. Date of Electronic Publication: 2024 May 08.
DOI:	10.1111/acer.15338
Abstrakt:	Evidence suggests that a relationship exists between the gut microbiome and the pathogenesis of alcohol use disorder (AUD) and alcohol-associated liver disease (AALD). This systematic review identified studies that investigated the gut microbiome in individuals with an AUD or an AALD. A search was conducted on October 27, 2022, in PubMed, Web of Science, and Embase databases. Fifty studies satisfied eligibility criteria. Most studies found evidence for gut dysbiosis in individuals with AUD and AALD. Microbiome intervention studies have mostly been conducted in AALD patients; fecal microbial transplant interventions show the most promise. Because most studies were conducted cross-sectionally, the causal relationship between the gut microbiome and alcohol use is unknown. Furthermore, almost all studies have been conducted in predominantly male populations, leaving critical questions regarding sex differences and generalizability of the findings. The study summaries and recommendations provided in this review seek to identify areas for further research and to highlight potential gut microbial interventions for treating AUD and AALD. (© 2024 Research Society on Alcohol.)
Databáze:	MEDLINE
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