Three novel dihydrochalcones from Flemingia lineata (L.) W.T. Aiton and their antiplasmodial activity.

Autor: Saputri RD; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia., Wati FA; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia., Purnamasari AP; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia., Ilmi H; Center of Natural Products Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia., Tjahjandarie TS; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia., Mardhiyyah S; Center of Natural Products Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia., Tanjung M; Center of Natural Products Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 May 08, pp. 1-8. Date of Electronic Publication: 2024 May 08.
DOI: 10.1080/14786419.2024.2349246
Abstrakt: Three novel dihydrochalcones, flemilineatins C-E ( 1-3 ), and two known flavanones ( 4-5 ) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1-3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1-5 were assayed to Plasmodium falciparum lactate dehydrogenase ( Pf LDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC 50 value of 0.74 and 0.79 µg/mL, respectively.
Databáze: MEDLINE