| Autor: |
Heier JL, Boselli DJ, Parker LL |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 24. Date of Electronic Publication: 2024 Apr 24. |
| DOI: |
10.1101/2024.04.24.590988 |
| Abstrakt: |
Novel time-resolved terbium luminescence assays were developed for CDK5 and CDK2 by designing synthetic substrates which incorporate phospho-inducible terbium sensitizing motifs with kinase substrate consensus sequences. Substrates designed for CDK5 showed no phosphorylation by CDK2, opening the possibility for CDK5-specific assay development for selective drug discovery. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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