Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma.
| Autor: | Harb F; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin., Liuzzi MT; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin., Huggins AA; Department of Psychology, University of Arizona, Tucson, Arizona., Webb EK; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, Massachusetts., Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee, Wisconsin., Krukowski JL; Department of Psychology, Marquette University, Milwaukee, Wisconsin., deRoon-Cassini TA; Department of Surgery, Division of Trauma and Acute Care Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin., Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. |
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| Jazyk: | angličtina |
| Zdroj: | Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2024 Apr 04; Vol. 4 (4), pp. 100312. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024). |
| DOI: | 10.1016/j.bpsgos.2024.100312 |
| Abstrakt: | Background: Childhood abuse (physical, emotional, and sexual) is associated with aberrant connectivity of the amygdala, a key threat-processing region. Heightened amygdala activity also predicts adult anxiety and posttraumatic stress disorder (PTSD) symptoms, as do experiences of childhood abuse. The current study explored whether amygdala resting-state functional connectivity may explain the relationship between childhood abuse and anxiety and PTSD symptoms following trauma exposure in adults. Methods: Two weeks posttrauma, adult trauma survivors ( n = 152, mean age [SD] = 32.61 [10.35] years; women = 57.2%) completed the Childhood Trauma Questionnaire and underwent resting-state functional magnetic resonance imaging. PTSD and anxiety symptoms were assessed 6 months posttrauma. Seed-to-voxel analyses evaluated the association between childhood abuse and amygdala resting-state functional connectivity. A mediation model evaluated the potential mediating role of amygdala connectivity in the relationship between childhood abuse and posttrauma anxiety and PTSD. Results: Childhood abuse was associated with increased amygdala connectivity with the precuneus while covarying for age, gender, childhood neglect, and baseline PTSD symptoms. Amygdala-precuneus resting-state functional connectivity was a significant mediator of the effect of childhood abuse on anxiety symptoms 6 months posttrauma ( B = 0.065; 95% CI, 0.013-0.130; SE = 0.030), but not PTSD. A secondary mediation analysis investigating depression as an outcome was not significant. Conclusions: Amygdala-precuneus connectivity may be an underlying neural mechanism by which childhood abuse increases risk for anxiety following adult trauma. Specifically, this heightened connectivity may reflect attentional vigilance for threat or a tendency toward negative self-referential thoughts. Findings suggest that childhood abuse may contribute to longstanding upregulation of attentional vigilance circuits, which makes one vulnerable to anxiety-related symptoms in adulthood. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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