Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank.

Autor: Kemper KE; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. k.kemper@uq.edu.au., Sidorenko J; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Wang H; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Hayes BJ; Queensland Alliance for Agriculture and Food Innovation, University of Queensland, Brisbane, QLD, Australia., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.; Department of Psychiatry, University of Oxford, Oxford, UK., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia., Keller MC; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., Goddard M; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, VIC, Australia.; Biosciences Research Division, Agriculture Victoria, Bundoora, VIC, Australia., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia. peter.visscher@uq.edu.au.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK. peter.visscher@uq.edu.au.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 06; Vol. 15 (1), pp. 3776. Date of Electronic Publication: 2024 May 06.
DOI: 10.1038/s41467-024-47802-7
Abstrakt: The causes of temporal fluctuations in adult traits are poorly understood. Here, we investigate the genetic determinants of within-person trait variability of 8 repeatedly measured anthropometric traits in 50,117 individuals from the UK Biobank. We found that within-person (non-directional) variability had a SNP-based heritability of 2-5% for height, sitting height, body mass index (BMI) and weight (P ≤ 2.4 × 10 - 3 ). We also analysed longitudinal trait change and show a loss of both average height and weight beyond about 70 years of age. A variant tracking the Alzheimer's risk APOE- E 4 allele (rs429358) was significantly associated with weight loss ( β  = -0.047 kg per yr, s.e. 0.007, P = 2.2 × 10 -11 ), and using 2-sample Mendelian Randomisation we detected a relationship consistent with causality between decreased lumbar spine bone mineral density and height loss (b xy  = 0.011, s.e. 0.003, P = 3.5 × 10 -4 ). Finally, population-level variance quantitative trait loci (vQTL) were consistent with within-person variability for several traits, indicating an overlap between trait variability assessed at the population or individual level. Our findings help elucidate the genetic influence on trait-change within an individual and highlight disease risks associated with these changes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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