Synthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalation.
| Autor: | Karabıyık H; Faculty of Science, Department of Physics, Dokuz Eylül University, Izmir 35390, Turkey., Karaer Tunçay A; Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, Turkey., Ilhan S; Department of Biology, Faculty of Engineering and Natural Sciences Manisa Celal Bayar University, Manisa 45140, Turkey., Atmaca H; Department of Biology, Faculty of Engineering and Natural Sciences Manisa Celal Bayar University, Manisa 45140, Turkey., Türkmen H; Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2024 Apr 17; Vol. 9 (17), pp. 19136-19147. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024). |
| DOI: | 10.1021/acsomega.3c10265 |
| Abstrakt: | A series of aryl-isatin Schiff base derivatives ( 3a - d ) and their piano-stool ruthenium complexes ( 4a - d ) were synthesized and characterized via 1 H and 13 C NMR and Fourier transform infrared (FTIR) spectroscopy. In addition, the purity of all of the compounds ( 3a - c and 4a - d ) was determined via elemental analysis. Complex 4d was analyzed using X-ray crystallography. An in vitro antiproliferative study of the compounds ( 3a - c and 4a - d ) against human hepatocellular carcinoma (HEPG2), human breast cancer (MCF-7), human prostate cancer (PC-3), and human embryonic kidney (HEK-293) cells exhibited their considerable antiproliferative activity. 4d exhibited effective cytotoxicity against HEPG2 and MCF-7. It displayed higher cytotoxicity than the reference metallo-drug cisplatin. Moreover, the stability of 4d was studied via 1 H NMR spectroscopy, and the binding model between 4d and DNA was investigated via ultraviolet-visible spectroscopy. The lipophilicity of the synthesized complexes was determined using an extraction method. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
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