Impact of booster vaccination interval on SARS-CoV-2 infection, hospitalization, and death.

Autor:	Lin DY; University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC. Electronic address: lin@bios.unc.edu., Xu Y; University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC., Gu Y; University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC., Sunny SK; CDC Foundation, North Carolina Department of Health and Human Services, Raleigh, NC., Moore Z; North Carolina Department of Health and Human Services, Raleigh, NC., Zeng D; University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2024 Aug; Vol. 145, pp. 107084. Date of Electronic Publication: 2024 May 03.
DOI:	10.1016/j.ijid.2024.107084
Abstrakt:	Objectives: We investigated how booster interval affects the risks of SARS-CoV-2 infection and Covid-19-related hospitalization and death in different age groups. Methods: We collected data on booster receipts and Covid-19 outcomes between September 22, 2021 and February 9, 2023 for 5,769,205 North Carolina residents ≥12 years of age who had completed their primary vaccination series. We related Covid-19 outcomes to baseline characteristics and booster doses through Cox regression models. Results: For adults ≥65 years of age, boosting every 9 months was associated with proportionate reductions (compared with no boosting) of 18.9% (95% CI, 18.5-19.4) in the cumulative frequency of infection, 37.8% (95% CI, 35.3-40.3) in the cumulative risk of hospitalization or death, and 40.9% (95% CI, 37.2-44.7) in the cumulative risk of death at 2 years after completion of primary vaccination. The reductions were lower by boosting every 12 months and higher by boosting every 6 months. The reductions were smaller for individuals 12-64 years of age. Conclusion: Boosting at a shorter interval was associated with a greater reduction in Covid-19 outcomes, especially hospitalization and death. Frequent boosting conferred greater benefits for individuals aged ≥65 than for individuals aged 12-64. (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu