Advancing oral health: Harnessing the potential of chitosan and polyphenols in innovative mouthwash formulation.

Autor: Maj M; Tissue Engineering Department, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza str 24 85-092, Bydgoszcz, Poland., Tylkowski B; Eurecat, Centre Tecnològic de Catalunya, Unitat de Tecnologia Química, Marcel·lí Domingo 2, Tarragona 43007, Spain; Department of Clinical Neuropsychology, Faculty of Health Science, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun ul. Sklodowskiej Curie 9, Bydgoszcz 85-094, Poland. Electronic address: bartosz.tylkowski@eurecat.org., Konopka P; Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, Poznan 61-614, Poland., Woźniak-Budych M; NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, Poznan 61-614, Poland., Staszak K; Institute of Technology and Chemical Engineering, Poznan University of Technology, Berdychowo 4, Poznan 60-965, Poland., Staszak M; Institute of Technology and Chemical Engineering, Poznan University of Technology, Berdychowo 4, Poznan 60-965, Poland., Kaźmierski Ł; Tissue Engineering Department, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza str 24 85-092, Bydgoszcz, Poland., Bajek A; Tissue Engineering Department, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza str 24 85-092, Bydgoszcz, Poland., Jastrzab R; Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, Poznan 61-614, Poland. Electronic address: renatad@amu.edu.pl.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jun; Vol. 175, pp. 116654. Date of Electronic Publication: 2024 Apr 30.
DOI: 10.1016/j.biopha.2024.116654
Abstrakt: This paper explores the therapeutic perspectives of polyphenols and chitosan as potential anticancer agents in the mouthwash formulations. Taking into account the high incidence of squamous cell carcinoma (SCC) among oral cancers, this discussion will concentrate on the potential advantages of these compounds in oral care, focusing on their impact on improving oral health and cancer prevention. According to the data, it appears that the mixture of BACs extract and chitosan may increase the efficiency of the apoptosis of cancer cells while reducing the undesired side effects. The cytotoxicity assays demonstrate a significant reduction in squamous carcinoma cell viability after incubation with BACs extract, with a marked decrease observed over 24-72 hours up to 76%. The anti-cancer properties of the BAC extract are related to luteolin, which is a predominant compound. The addition of 0.025% chitosan reduced the metabolic activity of cancer cells by 37.5%, suggesting a synergistic interaction between the compounds. This research highlights the potential of BACs and chitosan in modulating important molecular targets associated with cancer cell.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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