Melatonin prevents pulmonary fibrosis caused by PM 2.5 exposure by targeting epithelial-mesenchymal transition.
Autor: | Chen PC; School of Life Science, National Taiwan Normal University, Taipei, Taiwan; Translational medicine center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei City, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan., Yen MH; Department of Chest Surgery, Cathay General Hospital, New Taipei City, Taiwan., Hsiao SY; Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan; Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan., Kao WC; Division of Hematology-Oncology, Department of Internal Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan., Wang MT; Division of Physical Medicine and Rehabilitation, Fu Jen Catholic University Hospital, Taipei, Taiwan, ROC., Chiou PC; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan., Chao CC; Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address: 095457@mail.fju.edu.tw. |
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Jazyk: | angličtina |
Zdroj: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Jun; Vol. 487, pp. 116949. Date of Electronic Publication: 2024 Apr 28. |
DOI: | 10.1016/j.taap.2024.116949 |
Abstrakt: | Pulmonary fibrosis is a lung disorder characterized by the accumulation of abnormal extracellular matrix, scar tissue formation, and tissue stiffness. Type II alveolar epithelial cells (AEII) play a critical role in repairing lung tissue after injury, and repeated injury to these cells is a key factor in the development of pulmonary fibrosis. Chronic exposure to PM Competing Interests: Declaration of competing interest The authors state no conflict of interest. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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