Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Autor: Sarges KML; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Póvoa da Costa F; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Santos EFD; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Cantanhede MHD; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., da Silva R; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Veríssimo AOL; Center for Biological Health Sciences, State University of Pará, Tucuruí 68455-210, Brazil., Viana MNDSA; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Rodrigues FBB; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Leite MM; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil., Torres MKDS; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil., Bentes da Silva C; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil., Brito MTFM; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Clinical Analysis, Federal University of Pará, Belem 66000-000, Brazil., Silva ALSD; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Clinical Analysis, Federal University of Pará, Belem 66000-000, Brazil., Henriques DF; Section of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 67000-000, Brazil., Vallinoto IMVC; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil., Viana GMR; Malaria Basic Research Laboratory, Parasitology Section, Evandro Chagas Institute, Health Surveillance Secretariat, Brazilian Ministry of Health, Ananindeua 67000-000, Brazil., Queiroz MAF; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil., Vallinoto ACR; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.; Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil., Santos EJMD; Laboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Biology of Infectious and Parasitic Agents, Federal University of Pará, Belem 66000-000, Brazil.; Graduate Program in Clinical Analysis, Federal University of Pará, Belem 66000-000, Brazil.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2024 Apr 22; Vol. 16 (4). Date of Electronic Publication: 2024 Apr 22.
DOI: 10.3390/v16040650
Abstrakt: Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere ( n = 150) and severe ( n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.
Databáze: MEDLINE
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