Coenzyme Q10 and Autoimmune Disorders: An Overview.

Autor: Mantle D; Pharma Nord (UK) Ltd., Morpeth NE61 2DB, UK., Hargreaves IP; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 22; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 22.
DOI: 10.3390/ijms25084576
Abstrakt: Some 90 autoimmune disorders have been described in medical literature, affecting most of the tissues within the body. Autoimmune disorders may be difficult to treat, and there is a need to develop novel therapeutic strategies for these disorders. Autoimmune disorders are characterised by mitochondrial dysfunction, oxidative stress, and inflammation; there is therefore a rationale for a role for coenzyme Q10 in the management of these disorders, on the basis of its key role in normal mitochondrial function, as an antioxidant, and as an anti-inflammatory agent. In this article, we have therefore reviewed the potential role of CoQ10, in terms of both deficiency and/or supplementation, in a range of autoimmune disorders.
Competing Interests: Mantle is a medical adviser to Pharma Nord (UK) Ltd.
Databáze: MEDLINE
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