Clinical correlates of negative health events and disparities among adults with epilepsy enrolled in a self-management clinical trial.

Autor: Ghearing GR; Department of Neurology, Carver College of Medicine University of Iowa Health Center, Iowa City, LA, USA. Electronic address: gena-ghearing@uiowa.edu., Tyrrell M; Department of Neurology, Carver College of Medicine University of Iowa Health Center, Iowa City, LA, USA., Black J; Department of Psychiatry and of Neurology, Neurological & Behavioral Outcomes Center, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH, USA., Krehel-Montgomery J; Neurological & Behavioral Outcomes Center, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH, USA., Yala J; Neurological & Behavioral Outcomes Center, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH, USA., Adeniyi C; Neurological & Behavioral Outcomes Center, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH, USA., Briggs F; Department of Public Health Services, University of Miami Miller School of Medicine, Miami, FL, USA., Sajatovic M; Department of Psychiatry and of Neurology, Neurological & Behavioral Outcomes Center, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH, USA.
Jazyk: angličtina
Zdroj: Epilepsy research [Epilepsy Res] 2024 Jul; Vol. 203, pp. 107366. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.1016/j.eplepsyres.2024.107366
Abstrakt: Aims: Despite advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits and hospitalizations. This analysis using baseline data from an epilepsy self-management clinical trial targeting people from rural regions and other underserved populations assessed the relationship between demographic and clinical variables vs. NHEs.
Methods: Data to evaluate disparities and clinical correlates was collected using patient surveys from a baseline sample of 94 participants in a larger prospective study of 160 individuals with epilepsy who experienced an NHE within the last six months. Demographic characteristics, mental and physical functional status assessed using 36-Item Short Form Health Survey questionnaire version 2 (SF-36v2), depression assessed with the 9-item Patient Health Questionnaire (PHQ-9), quality of life assessed with the 10-item Quality of Life in Epilepsy Inventory (QOLIE-10), self-efficacy assessed the Epilepsy Self-Efficacy Scale (ESES), social support assessed with the Multidimensional Scale of Perceived Social Support (MSPSS), self-management assessed with the Epilepsy Self-Management Scale (ESMS), and stigma assessed with the Epilepsy Stigma Scale (ESS) were all examined in association with past 6-month total NHE frequency as well as NHE sub-categories of past 30-day and 6-month seizure counts, self-harm attempts, ED visits and hospitalizations. An exploratory evaluation of NHE correlates in relation to the Rural Urban Continuum Code (RUCC) residence classification compared 3 subgroups of increasing rurality. Descriptive statistics were generated for demographic and clinical variables and NHEs, and exploratory analyses compared the distribution of demographic, clinical, and NHE variables by RUCC categorization.
Results: The mean age was 38.5 years (SD 11.9), predominantly female (N= 62, 66.0%) and white (N=81, 86.2%). Just a little under half (N=43, 45.7%) of participants had annual incomes of less than $25,000, and 40% (N=38) were rural residents (RUCC >3). The past 6-month NHEs count was 20.4 (SD 32.0). Seizures were the most common NHE with a mean 30-day seizure frequency = 5.4 (SD 11.8) and 6-month seizure frequency of 18.7 (SD 31.6). Other NHE types were less common with a past 6-month self-harm frequency of 0.16 (SD 1.55), ED visit frequency of 0.72 (SD 1.10), and hospitalization frequency of 0.28 (SD 1.02). There were few significant demographic and clinical correlates for total and sub-categories of NHEs. Worse physical health status, as measured by the physical component summary (PCS) of the SF-36v2, was significantly associated with 6-month seizure counts (p=.04). There were no significant differences between the 3 RUCC subgroups on demographic variables. However, past 30-day seizure count, past 6-month seizure count and total past 6-month NHE counts were all higher among individuals from more rural settings (p-values <.01 for each).
Conclusions: Rural adults with epilepsy were more likely to have a greater number of seizures and more epilepsy complications in general. Worse physical health function was also associated with more epilepsy complications. However, this analysis found few other demographic and clinical correlates of cumulative NHEs among adults with epilepsy. Additional efforts are needed to investigate health disparities among people with epilepsy who live in rural regions or who have poor physical health function.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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