| Autor: |
Styliara EI; Department of Radiology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Astrakas LG; Medical Physics Lab, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Alexiou G; Department of Neurosurgery, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Xydis VG; Department of Radiology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Zikou A; Department of Radiology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Kafritsas G; Department of Neurosurgery, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Voulgaris S; Department of Neurosurgery, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece., Argyropoulou MI; Department of Radiology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece. |
| Abstrakt: |
Background: Extracting multiregional radiomic features from multiparametric MRI for predicting pretreatment survival in isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) patients is a promising approach. Methods: MRI data from 49 IDH wild-type glioblastoma patients pre-treatment were utilized. Diffusion and perfusion maps were generated, and tumor subregions segmented. Radiomic features were extracted for each tissue type and map. Feature selection on 1862 radiomic features identified 25 significant features. The Cox proportional-hazards model with LASSO regularization was used to perform survival analysis. Internal and external validation used a 38-patient training cohort and an 11-patient validation cohort. Statistical significance was set at p < 0.05. Results: Age and six radiomic features (shape and first and second order) from T1W, diffusion, and perfusion maps contributed to the final model. Findings suggest that a small necrotic subregion, inhomogeneous vascularization in the solid non-enhancing subregion, and edema-related tissue damage in the enhancing and edema subregions are linked to poor survival. The model's C-Index was 0.66 (95% C.I. 0.54-0.80). External validation demonstrated good accuracy (AUC > 0.65) at all time points. Conclusions: Radiomics analysis, utilizing segmented perfusion and diffusion maps, provide predictive indicators of survival in IDH wild-type glioblastoma patients, revealing associations with microstructural and vascular heterogeneity in the tumor. |
