Association of Interleukin-4 Receptor α Chain I50V Gene Variant (rs1805010) and Asthma in Iranian Population: A Case-control Study.

Autor:	Mowahedi M; Abortion Research Center, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Aramesh A; Thalassemia and Hemophilia Research Center, Shahid Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran., Khouzani MS; Cellular and Molecular Biology - Genetic Center, Falavarjan Azad University, Isfahan, Iran., Khouzani MS; Cellular and Molecular Biology - Genetic Center, Falavarjan Azad University, Isfahan, Iran., Daryanoush S; Thalassemia and Hemophilia Research Center, Shahid Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran., Samet M; Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Samadi M; Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Jazyk:	angličtina
Zdroj:	The open respiratory medicine journal [Open Respir Med J] 2024 Jan 10; Vol. 18, pp. e18743064266613. Date of Electronic Publication: 2024 Jan 10 (Print Publication: 2024).
DOI:	10.2174/0118743064266613231123103523
Abstrakt:	Background: Asthma is one of the respiratory disorders caused by chronic airway inflammation. IL-4 has been identified as one of the participating interleukins in the severity of asthma. Objective: A case-control study was conducted to determine the association of rs1805010, a single nucleotide polymorphism in the interleukin 4 receptor α chain, with asthma and immunoglobulin E and IL-17A serum levels in Iranian populations. Methods: ELISA was used to investigate the relationship between three different varieties of SNP I50V and serum IL-17A levels, as well as total IgE levels. Based on GINA criteria, patients were classified into mild, moderate, and severe groups based on the association between SNP I50V, IL-17A, and total IgE. In order to analyze the data, the student-t-test and the one-way ANOVA were used. Results: The SNP I50V was associated with asthma in a significant way (p = 0.001). IL-17A and total IgE levels were significantly higher in asthmatic patients than in control participants (p 0.05 and p 0.021, respectively), but neither showed any association with SNP I50V in the asthmatic patients. Conclusion: Asthma patients have a higher prevalence of the I allele, reflecting the significance of Th2 cells. Although total IgE and IL-17A levels increased in both disease subgroups, total IgE level augmentation correlates directly with disease severity, while IL-17A level enhancement does not. Competing Interests: The authors declare no conflict of interest, financial or otherwise. (© 2024 Mowahedi et al.)
Databáze:	MEDLINE
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