Early Screening for the Parkinson Variant of Multiple System Atrophy: A 6-Item Score.

Autor: Fanciulli A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Stankovic I; Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Avraham O; Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Jecmenica Lukic M; Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Ezra A; Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel., Leys F; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Goebel G; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria., Krismer F; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Petrovic I; Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Svetel M; Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Seppi K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Neurology, Provincial Hospital of Kufstein, Kufstein, Austria., Kostic V; Neurology Clinic, University Clinical Center of Serbia, Belgrade, Serbia.; Faculty of Medicine, University of Belgrade, Belgrade, Serbia., Giladi N; Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Poewe W; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Wenning GK; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Gurevich T; Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2024 Apr 24. Date of Electronic Publication: 2024 Apr 24.
DOI: 10.1002/mdc3.14048
Abstrakt: Background: A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity.
Objectives: To replicate and improve the 4-item MSA-P score.
Methods: We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up.
Results: The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0-6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity.
Conclusions: The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.
(© 2024 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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