Modular horizontal network within mouse primary visual cortex.

Autor:	Burkhalter A; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States., Ji W; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States., Meier AM; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.; Department of Speech, Language and Hearing Sciences, College of Engineering, Boston University, Boston, MA, United States., D'Souza RD; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroanatomy [Front Neuroanat] 2024 Apr 08; Vol. 18, pp. 1364675. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).
DOI:	10.3389/fnana.2024.1364675
Abstrakt:	Interactions between feedback connections from higher cortical areas and local horizontal connections within primary visual cortex (V1) were shown to play a role in contextual processing in different behavioral states. Layer 1 (L1) is an important part of the underlying network. This cell-sparse layer is a target of feedback and local inputs, and nexus for contacts onto apical dendrites of projection neurons in the layers below. Importantly, L1 is a site for coupling inputs from the outside world with internal information. To determine whether all of these circuit elements overlap in L1, we labeled the horizontal network within mouse V1 with anterograde and retrograde viral tracers. We found two types of local horizontal connections: short ones that were tangentially limited to the representation of the point image, and long ones which reached beyond the receptive field center, deep into its surround. The long connections were patchy and terminated preferentially in M2 muscarinic acetylcholine receptor-negative (M2-) interpatches. Anterogradely labeled inputs overlapped in M2-interpatches with apical dendrites of retrogradely labeled L2/3 and L5 cells, forming module-selective loops between topographically distant locations. Previous work showed that L1 of M2-interpatches receive inputs from the lateral posterior thalamic nucleus (LP) and from a feedback network from areas of the medial dorsal stream, including the secondary motor cortex. Together, these findings suggest that interactions in M2-interpatches play a role in processing visual inputs produced by object-and self-motion. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Burkhalter, Ji, Meier and D’Souza.)
Databáze:	MEDLINE
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