Rates and Predictors of Rapid Eye Movement Sleep Behavior Disorder Symptoms Among Post-9/11 Veterans.

Autor:	Jones MB; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Tea J; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Meyers M; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Li R; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Villalon A; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Agrawal R; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li)., Jorge RE; Mental Health Care Line (Jones, Jorge), Research Care Line (Jones, Villalon), and Medical Care Line (Agrawal), Michael E. DeBakey Veterans Affairs (VA) Medical Center, Houston; Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Menninger Department of Psychiatry and Behavioral Sciences (Jones, Villalon, Jorge), and Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine (Agrawal), Baylor College of Medicine, Houston; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Tea); Division of Clinical Pharmacology, Department of Medicine, and Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Meyers); Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center, Houston (Li).
Jazyk:	angličtina
Zdroj:	The Journal of neuropsychiatry and clinical neurosciences [J Neuropsychiatry Clin Neurosci] 2024 Fall; Vol. 36 (4), pp. 325-332. Date of Electronic Publication: 2024 Apr 23.
DOI:	10.1176/appi.neuropsych.20230106
Abstrakt:	Objective: Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI), which are prevalent conditions among post-9/11 veterans, increase risks of rapid eye movement (REM) sleep behavior disorder (RBD) and degenerative synucleinopathy. Rates and predictors of RBD symptoms were investigated by screening post-9/11 veterans for RBD with a validated questionnaire. Methods: In this cross-sectional analysis, consecutive patients in the Houston Translational Research Center for TBI and Stress Disorders (TRACTS) were screened with the English translation of the RBD Questionnaire-Hong Kong (RBDQ-HK). In addition to data from the standard TRACTS battery, systematic chart review was used to identify known sleep disorders mimicking or manifesting RBD. Results: Of the 119 patients with available RBDQ-HK scores, 71 (60%) and 65 (55%) screened positive for RBD, when a total score ≥21 and a factor 2 score ≥8 were used as cutoff scores, respectively. Univariable analyses with both cutoffs showed consistent associations between a positive RBDQ-HK screen and global sleep quality, number of TBI exposures, and PTSD severity. Multivariable logistic regression with total score ≥21 as a cutoff indicated that PTSD severity (odds ratio=1.06, 95% CI=1.02-1.10) and number of TBIs (odds ratio=1.63, 95% CI=1.16-2.41) were independent predictors of a positive screen, whereas global sleep quality was no longer significant. Multivariable logistic regression with factor 2 score ≥8 as a cutoff showed similar results. Conclusions: Interdisciplinary parasomnia assessment, further validation of RBD screens, and standardized reporting of REM sleep without atonia could provide necessary information on the pathophysiological relationships linking PTSD, TBI, RBD symptoms, and ultimately synucleinopathy risk among post-9/11 veterans. Competing Interests: Drs. Jones, Li, and Jorge have received study drug support from Acadia Pharmaceuticals. Dr. Jorge has received study drug support for a VA Cooperative Studies Program trial from Pfizer Pharmaceuticals. The other authors report no financial relationships with commercial interests.
Databáze:	MEDLINE
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