Critical role of miR-21/exosomal miR-21 in autophagy pathway.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan., Mahdi MS; College of MLT, Ahl Al Bayt University, Iraq., Allela OQB; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq., Alazzawi TS; College of dentist, National University of Science and Technology, Dhi Qar, Iraq., Ubaid M; Medical technical college, Al-Farahidi University, Iraq., Rakhimov NM; Department of Oncology, Samarkand State Medical University, 18 Amir Temur Street, Samarkand, Uzbekistan; Department of Oncology, Tashkent State Dental Institute, Tashkent, Uzbekistan., Athab ZH; Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq., Ramaiah P; College of MLT, Ahl Al Bayt University, Iraq., Chinnasamy L; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan., Alsaikhan F; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia jSchool of Pharmacy, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. Electronic address: fsaikhan@hotmail.com., Farhood B; Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: farhood-b@kaums.ac.ir.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 May; Vol. 257, pp. 155275. Date of Electronic Publication: 2024 Mar 30.
DOI: 10.1016/j.prp.2024.155275
Abstrakt: Activation of autophagy, a process of cellular stress response, leads to the breakdown of proteins, organelles, and other parts of the cell in lysosomes, and can be linked to several ailments, such as cancer, neurological diseases, and rare hereditary syndromes. Thus, its regulation is very carefully monitored. Transcriptional and post-translational mechanisms domestically or in whole organisms utilized to control the autophagic activity, have been heavily researched. In modern times, microRNAs (miRNAs) are being considered to have a part in post-translational orchestration of the autophagic activity, with miR-21 as one of the best studied miRNAs, it is often more than expressed in cancer cells. This regulatory RNA is thought to play a major role in a plethora of processes and illnesses including growth, cancer, cardiovascular disease, and inflammation. Different studies have suggested that a few autophagy-oriented genes, such as PTEN, Rab11a, Atg12, SIPA1L2, and ATG5, are all targeted by miR-21, indicating its essential role in the regulation.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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