Activity-Dependent Ectopic Spiking in Parvalbumin-Expressing Interneurons of the Neocortex.
| Autor: | Theyel BB; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02912 brian_theyel@brown.edu.; Department of Neuroscience, Brown University, Providence, Rhode Island 02912.; Care New England Medical Group, Providence, Rhode Island 02906., Stevenson RJ; Department of Neuroscience, Brown University, Providence, Rhode Island 02912., Connors BW; Department of Neuroscience, Brown University, Providence, Rhode Island 02912. |
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| Jazyk: | angličtina |
| Zdroj: | ENeuro [eNeuro] 2024 May 03; Vol. 11 (5). Date of Electronic Publication: 2024 May 03 (Print Publication: 2024). |
| DOI: | 10.1523/ENEURO.0314-23.2024 |
| Abstrakt: | Canonically, action potentials of most mammalian neurons initiate at the axon initial segment (AIS) and propagate bidirectionally: orthodromically along the distal axon and retrogradely into the soma and dendrites. Under some circumstances, action potentials may initiate ectopically, at sites distal to the AIS, and propagate antidromically along the axon. These "ectopic action potentials" (EAPs) have been observed in experimental models of seizures and chronic pain, and more rarely in nonpathological forebrain neurons. Here we report that a large majority of parvalbumin-expressing (PV+) interneurons in the upper layers of mouse neocortex, from both orbitofrontal and primary somatosensory areas, fire EAPs after sufficient activation of their somata. Somatostatin-expressing interneurons also fire EAPs, though less robustly. Ectopic firing in PV+ cells occurs in varying temporal patterns and can persist for several seconds. PV+ cells evoke strong synaptic inhibition in pyramidal neurons and interneurons and play critical roles in cortical function. Our results suggest that ectopic spiking of PV+ interneurons is common and may contribute to both normal and pathological network functions of the neocortex. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Theyel et al.) |
| Databáze: | MEDLINE |
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