Recent trends in bone tissue engineering: a review of materials, methods, and structures.

Autor:	Moghaddam A; Iran Polymer and Petrochemical Institute (IPPI), Tehran 14965-115, Iran., Bahrami M; Department of Mechanical Engineering and Mechanics, Lehigh University, 27 Memorial Dr W, Bethlehem, PA 18015, United States of America., Mirzadeh M; Iran Polymer and Petrochemical Institute (IPPI), Tehran 14965-115, Iran., Khatami M; Iran Polymer and Petrochemical Institute (IPPI), Tehran 14965-115, Iran., Simorgh S; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran., Chimehrad M; Department of Mechanical & Aerospace Engineering, College of Engineering & Computer Science, University of Central Florida, Orlando, FL, United States of America., Kruppke B; Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, Germany., Bagher Z; Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran., Mehrabani D; Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Fars 71348-14336, Iran.; Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars 71345-1744, Iran., Khonakdar HA; Iran Polymer and Petrochemical Institute (IPPI), Tehran 14965-115, Iran.; Max Bergmann Center of Biomaterials and Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, Germany.
Jazyk:	angličtina
Zdroj:	Biomedical materials (Bristol, England) [Biomed Mater] 2024 May 29; Vol. 19 (4). Date of Electronic Publication: 2024 May 29.
DOI:	10.1088/1748-605X/ad407d
Abstrakt:	Bone tissue engineering (BTE) provides the treatment possibility for segmental long bone defects that are currently an orthopedic dilemma. This review explains different strategies, from biological, material, and preparation points of view, such as using different stem cells, ceramics, and metals, and their corresponding properties for BTE applications. In addition, factors such as porosity, surface chemistry, hydrophilicity and degradation behavior that affect scaffold success are introduced. Besides, the most widely used production methods that result in porous materials are discussed. Gene delivery and secretome-based therapies are also introduced as a new generation of therapies. This review outlines the positive results and important limitations remaining in the clinical application of novel BTE materials and methods for segmental defects. (© 2024 IOP Publishing Ltd.)
Databáze:	MEDLINE
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