A systematic review, meta-analysis and meta-regression amalgamating the driven approaches used to quantify dynamic cerebral autoregulation.

Autor:	Burma JS; Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Integrated Concussion Research Program, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada., Roy MA; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research Center of the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada., Kennedy CM; Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Integrated Concussion Research Program, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada., Labrecque L; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research Center of the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada., Brassard P; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada.; Research Center of the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Canada., Smirl JD; Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.; Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.; Integrated Concussion Research Program, University of Calgary, Calgary, Canada.; Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.; Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Aug; Vol. 44 (8), pp. 1271-1297. Date of Electronic Publication: 2024 Apr 18.
DOI:	10.1177/0271678X241235878
Abstrakt:	Numerous driven techniques have been utilized to assess dynamic cerebral autoregulation (dCA) in healthy and clinical populations. The current review aimed to amalgamate this literature and provide recommendations to create greater standardization for future research. The PubMed database was searched with inclusion criteria consisting of original research articles using driven dCA assessments in humans. Risk of bias were completed using Scottish Intercollegiate Guidelines Network and Methodological Index for Non-Randomized Studies. Meta-analyses were conducted for coherence, phase, and gain metrics at 0.05 and 0.10 Hz using deep-breathing, oscillatory lower body negative pressure (OLBNP), sit-to-stand maneuvers, and squat-stand maneuvers. A total of 113 studies were included, with 40 of these incorporating clinical populations. A total of 4126 participants were identified, with younger adults (18-40 years) being the most studied population. The most common techniques were squat-stands (n = 43), deep-breathing (n = 25), OLBNP (n = 20), and sit-to-stands (n = 16). Pooled coherence point estimates were: OLBNP 0.70 (95%CI:0.59-0.82), sit-to-stands 0.87 (95%CI:0.79-0.95), and squat-stands 0.98 (95%CI:0.98-0.99) at 0.05 Hz; and deep-breathing 0.90 (95%CI:0.81-0.99); OLBNP 0.67 (95%CI:0.44-0.90); and squat-stands 0.99 (95%CI:0.99-0.99) at 0.10 Hz. This review summarizes clinical findings, discusses the pros/cons of the 11 unique driven techniques included, and provides recommendations for future investigations into the unique physiological intricacies of dCA. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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