Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period.

Autor:	Zinno C; The BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy., Agnesi F; The BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy., D'Alesio G; The BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy., Dushpanova A, Brogi L; Bio@SNS, Scuola Normale Superiore, Pisa, Italy., Camboni D; The BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy., Bernini F; BioMedLab, Interdisciplinary Research Center 'Health Science,' Scuola Superiore Sant'Anna, Pisa, Italy., Terlizzi D; Fondazione Toscana 'G. Monasterio,' Pisa, Italy., Casieri V; Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center 'Health Science,' Scuola Superiore Sant'Anna, Pisa, Italy., Gabisonia K; BioMedLab, Interdisciplinary Research Center 'Health Science,' Scuola Superiore Sant'Anna, Pisa, Italy., Alibrandi L; Unit of Translational Critical Care Medicine, Laboratory of Basic and Applied Medical Sciences, Interdisciplinary Research Center 'Health Science,' Scuola Superiore Sant'Anna, Pisa, Italy., Grigoratos C; Fondazione Toscana 'G. Monasterio,' Pisa, Italy., Magomajew J; Department of Chemistry, Fraunhofer Institute for Microengineering and Microsystems, 55129 Mainz, Germany., Aquaro GD, Schmitt S; Department of Chemistry, Fraunhofer Institute for Microengineering and Microsystems, 55129 Mainz, Germany., Detemple P; Department of Chemistry, Fraunhofer Institute for Microengineering and Microsystems, 55129 Mainz, Germany., Oddo CM; The BioRobotics Institute, Department of Excellence in Robotics & AI, Scuola Superiore Sant'Anna, Pisa, Italy., Lionetti V, Micera S
Jazyk:	angličtina
Zdroj:	APL bioengineering [APL Bioeng] 2024 Apr 16; Vol. 8 (2), pp. 026102. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
DOI:	10.1063/5.0169207
Abstrakt:	The sensing of left ventricular (LV) activity is fundamental in the diagnosis and monitoring of cardiovascular health in high-risk patients after cardiac surgery to achieve better short- and long-term outcome. Conventional approaches rely on noninvasive measurements even if, in the latest years, invasive microelectromechanical systems (MEMS) sensors have emerged as a valuable approach for precise and continuous monitoring of cardiac activity. The main challenges in designing cardiac MEMS sensors are represented by miniaturization, biocompatibility, and long-term stability. Here, we present a MEMS piezoresistive cardiac sensor capable of continuous monitoring of LV activity over time following epicardial implantation with a pericardial patch graft in adult minipigs. In acute and chronic scenarios, the sensor was able to compute heart rate with a root mean square error lower than 2 BPM. Early after up to 1 month of implantation, the device was able to record the heart activity during the most important phases of the cardiac cycle (systole and diastole peaks). The sensor signal waveform, in addition, closely reflected the typical waveforms of pressure signal obtained via intraventricular catheters, offering a safer alternative to heart catheterization. Furthermore, histological analysis of the LV implantation site following sensor retrieval revealed no evidence of myocardial fibrosis. Our results suggest that the epicardial LV implantation of an MEMS sensor is a suitable and reliable approach for direct continuous monitoring of cardiac activity. This work envisions the use of this sensor as a cardiac sensing device in closed-loop applications for patients undergoing heart surgery. Competing Interests: The authors have no conflicts to disclose. (© 2024 Author(s).)
Databáze:	MEDLINE
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