In vivo T2 measurements of the fetal brain using single-shot fast spin echo sequences.

Autor: Bhattacharya S; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Price AN; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Guy's and St Thomas' NHS Foundation Trust, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Uus A; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Sousa HS; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK., Marenzana M; Centre for the Developing Brain, King's College London, London, UK., Colford K; Centre for the Developing Brain, King's College London, London, UK., Murkin P; Guy's and St Thomas' NHS Foundation Trust, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Lee M; Guy's and St Thomas' NHS Foundation Trust, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Cordero-Grande L; Biomedical Image Technologies, ETSI Telecomunicración, Universidad Politécnica de Madrid and CIBER-BBN, Madrid, Spain., Teixeira RPAG; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Malik SJ; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Centre for the Developing Brain, King's College London, London, UK., Deprez M; School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.; Centre for the Developing Brain, King's College London, London, UK.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2024 Aug; Vol. 92 (2), pp. 715-729. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.1002/mrm.30094
Abstrakt: Purpose: We propose a quantitative framework for motion-corrected T2 fetal brain measurements in vivo and validate the single-shot fast spin echo (SS-FSE) sequence to perform these measurements.
Methods: Stacks of two-dimensional SS-FSE slices are acquired with different echo times (TE) and motion-corrected with slice-to-volume reconstruction (SVR). The quantitative T2 maps are obtained by a fit to a dictionary of simulated signals. The sequence is selected using simulated experiments on a numerical phantom and validated on a physical phantom scanned on a 1.5T system. In vivo quantitative T2 maps are obtained for five fetuses with gestational ages (GA) 21-35 weeks on the same 1.5T system.
Results: The simulated experiments suggested that a TE of 400 ms combined with the clinically utilized TEs of 80 and 180 ms were most suitable for T2 measurements in the fetal brain. The validation on the physical phantom confirmed that the SS-FSE T2 measurements match the gold standard multi-echo spin echo measurements. We measured average T2s of around 200 and 280 ms in the fetal brain grey and white matter, respectively. This was slightly higher than fetal T2* and the neonatal T2 obtained from previous studies.
Conclusion: The motion-corrected SS-FSE acquisitions with varying TEs offer a promising practical framework for quantitative T2 measurements of the moving fetus.
(© 2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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