A review of the mesotheliogenic potency of cleavage fragments found in talc.

Autor:	Miller E; Benchmark Risk Group, Grand Rapids, MI, USA., Beckett EM; Benchmark Risk Group, Boston, MA, USA., Cheatham D; Benchmark Risk Group, Chicago, IL, USA., Comerford CE; Benchmark Risk Group, Chicago, IL, USA., Lewis RC; Benchmark Risk Group, Oakland, CA, USA., Krevanko C; Benchmark Risk Group, Seattle, WA, USA., Mandava N; Benchmark Risk Group, Denver, CO, USA., Pierce JS; Benchmark Risk Group, Chicago, IL, USA.
Jazyk:	angličtina
Zdroj:	Toxicology and industrial health [Toxicol Ind Health] 2024 Jul; Vol. 40 (7), pp. 398-424. Date of Electronic Publication: 2024 Apr 15.
DOI:	10.1177/07482337241246924
Abstrakt:	It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: All of the authors are employed by Benchmark Risk Group LLC, a consulting firm that provides scientific advice to the government, corporations, law firms, and various scientific/professional organizations. Benchmark Risk Group LLC has been engaged by companies involved in asbestos and talc litigation, and four of the authors (EM, EB, RL, and JP) have served and may serve again as experts in future cases. However, the time invested by the authors to write this paper was provided by their employer, and no client of Benchmark Risk Group LLC, or party in litigation requested that this work be performed. No external funding was received for the analysis, the research supporting the analysis, nor the time needed to prepare the article. Furthermore, the work product, including but not limited to the study design, results and conclusions drawn, is exclusively that of the authors, and no party to asbestos or talc litigation reviewed this paper prior to its publication.
Databáze:	MEDLINE
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