Constipation anti-aging effects by dairy-based lactic acid bacteria.

Autor:	Jaafar MH; Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia., Xu P; Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.; Faculty of Cuisine, Sichuan Tourism University, Chengdu 610100, China., Mageswaran UM; Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia., Balasubramaniam SD; Faculty of Medicine, AIMST University, Bedong 08100, Kedah, Malaysia., Solayappan M; Faculty of Applied Sciences, AIMST University, Bedong 08100, Kedah, Malaysia., Woon JJ; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia., Teh CS; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia., Todorov SD; ProBacLab, Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo 05508-090, Brazil., Park YH; Probionic Corp., Iksan 54576, Korea., Liu G; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China.; CAS-TWAS Centre of Excellence for Biotechnology, Beijing 100101, China., Liong MT; Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.; Renewable Biomass Transformation Cluster, School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.
Jazyk:	angličtina
Zdroj:	Journal of animal science and technology [J Anim Sci Technol] 2024 Jan; Vol. 66 (1), pp. 178-203. Date of Electronic Publication: 2024 Jan 31.
DOI:	10.5187/jast.2023.e93
Abstrakt:	Constipation, which refers to difficulties in defecation and infrequent bowel movement in emptying the gastrointestinal system that ultimately produces hardened fecal matters, is a health concern in livestock and aging animals. The present study aimed to evaluate the potential effects of dairy-isolated lactic acid bacteria (LAB) strains to alleviate constipation as an alternative therapeutic intervention for constipation treatment in the aging model. Rats were aged via daily subcutaneous injection of D-galactose (600 mg/body weight [kg]), prior to induction of constipation via oral administration of loperamide hydrochloride (5 mg/body weight [kg]). LAB strains ( L. fermentum USM 4189 or L. plantarum USM 4187) were administered daily via oral gavage (1 × 10 Log CFU/day) while the control group received sterile saline. Aged rats as shown with shorter telomere lengths exhibited increased fecal bulk and soften fecal upon administration of LAB strains amid constipation as observed using the Bristol Stool Chart, accompanied by a higher fecal moisture content as compared to the control ( p < 0.05). Fecal water-soluble metabolite profiles showed a reduced concentration of threonine upon administration of LAB strains compared to the control ( p < 0.05). Histopathological analysis also showed that the administration of LAB strains contributed to a higher colonic goblet cell count as compared to the control ( p < 0.05). The present study illustrates the potential of dairy-sourced LAB strains as probiotics to ameliorate the adverse effect of constipation amid aging, and as a potential dietary intervention strategy for dairy foods including yogurt and cheese. Competing Interests: No potential conflict of interest relevant to this article was reported. (© Copyright 2024 Korean Society of Animal Science and Technology.)
Databáze:	MEDLINE
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