| Autor: |
Lazareva L; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Suturina L; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Atalyan A; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Danusevich I; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Nadelyaeva I; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Belenkaya L; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Egorova I; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Ievleva K; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Babaeva N; Scientific Center for Family Health and Human Reproduction Problems, 664003 Irkutsk, Russia., Lizneva D; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Legro RS; Penn State College of Medicine, Penn State University, Hershey, PA 17033, USA., Azziz R; Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA. |
| Abstrakt: |
Polycystic ovary syndrome (PCOS) is a highly prevalent disorder in women, and its diagnosis rests on three principal features: ovulatory/menstrual dysfunction, clinical and/or biochemical hyperandrogenism, and polycystic ovarian morphology (PCOM). Currently, data on age- and ethnicity-dependent features of PCOM remain insufficient. We aimed to estimate ethnicity- and age-dependent differences in ovarian volume (OV) and follicle number per ovary (FNPO) in a healthy, medically unbiased population of Caucasian and Asian premenopausal women, who participated in the cross-sectional Eastern Siberia PCOS epidemiology and phenotype (ESPEP) study (ClinicalTrials.gov ID: NCT05194384) in 2016-2019. The study population consisted of 408 non-hirsute, normo-androgenic, eumenorrheic premenopausal women aged 18-44 years. All participants underwent a uniform evaluation including a review of their medical history and a physical examination, blood sampling, and pelvic ultrasonography. The statistical analysis included non-parametric tests and the estimation of the upper normal limits (UNLs) by 98th percentiles for OV and FNPO. In the total study population, the upper OV percentiles did not differ by ethnicity or age group. By contrast, the UNL of FNPO was higher in Caucasian women than in Asian women, and women aged <35 years demonstrated a higher UNL of FNPO compared to older women. In summary, these data suggest that the estimation of FNPO, but not OV, should take into account the ethnicity and age of the individual in estimating the presence of PCOM. |
