Incidence of liver cancer in young adults according to the Global Burden of Disease database 2019.

Autor:	Danpanichkul P; Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA., Aboona MB; Department of Internal Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA., Sukphutanan B; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Kongarin S; Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Duangsonk K; Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Ng CH; Department of Medicine, Division of Gastroenterology and Hepatology, National University Health System, Singapore.; Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Kurume, Japan., Muthiah MD; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Huang DQ; Department of Medicine, Division of Gastroenterology and Hepatology, National University Health System, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; MASLD Research Center, Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA., Seko Y; Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyou-ku, Kyoto, Japan., Díaz LA; Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Observatorio Multicéntrico de Enfermedades Gastrointestinales, OMEGA, Santiago, Chile., Arab JP; Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.; Department of Medicine, Division of Gastroenterology, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada.; Department of Epidemiology and Biostatistics, Schulich School of Medicine, Western University, London, Ontario, Canada., Yang JD; Karsh Division of Gastroenterology and Hepatology, Comprehensive Transplant Center, and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Chen VL; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Kim D; Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA., Noureddin M; Houston Research Institute and Houston Methodist Hospital, Houston, Texas, USA., Liangpunsakul S; Department of Medicine, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA., Wijarnpreecha K; Department of Medicine, Division of Gastroenterology and Hepatology, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Department of Internal Medicine, Banner University Medical Center, Phoenix, Arizona, USA.; BIO5 Institute, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona, USA.
Jazyk:	angličtina
Zdroj:	Hepatology (Baltimore, Md.) [Hepatology] 2024 Oct 01; Vol. 80 (4), pp. 828-843. Date of Electronic Publication: 2024 Apr 08.
DOI:	10.1097/HEP.0000000000000872
Abstrakt:	Background and Aims: The worldwide burden of cancer is increasing in younger populations. However, the epidemiology of primary liver cancer remains understudied in young adults compared to other cancer forms. Approach and Results: This study analyzed data from the Global Burden of Disease study between 2010 and 2019 to assess the age-standardized incidence, mortality, and disability-adjusted life years associated with primary liver cancer in the young (15-49 y), stratified by region, nation, sociodemographic index, and sex. The study found a global estimate of 78,299 primary liver cancer cases, 60,602 deaths, and 2.90 million disability-adjusted life years in the young population. The Western Pacific region exhibited the highest burden in 2019, showing the most significant increase compared to other regions between 2010 and 2019. More than half of the countries worldwide have undergone an increase in primary liver cancer incidence rates in young adults. Around 12.51% of deaths due to primary liver cancer occur in young individuals. Throughout the study period, there was a significant decline in primary liver cancer mortality due to most etiologies, except for metabolic dysfunction-associated steatotic liver disease-attributable primary liver cancer (annual percentage change + 0.87%, 95% CI: 0.70%-1.05%) and alcohol-attributable primary liver cancer (annual percentage change + 0.21%, 95% CI: 0.01%-0.42%). The limitations of the Global Burden of Disease database include reliance on the quality of primary data and possible underestimation of alcohol consumption. Conclusions: Over the past decade, there has been a marked increase in the burden of primary liver cancer, especially that originating from steatotic liver disease. This trend calls for the development of urgent and comprehensive strategies to mitigate this rising burden globally. (Copyright © 2024 American Association for the Study of Liver Diseases.)
Databáze:	MEDLINE
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