Conjugal Synucleinopathies: A Clinicopathologic Study.

Autor: Adler CH; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Halverson M; Unaffiliated., Zhang N; Department of Biostatistics, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Shill HA; Barrow Neurologic Institute, Phoenix, Arizona, USA., Driver-Dunckley E; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Mehta SH; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Atri A; Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, Arizona, USA.; Center for Brain/Mind Medicine, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Caviness JN; Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA., Serrano GE; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA., Shprecher DR; Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, Arizona, USA., Belden CM; Cleo Roberts Center, Banner Sun Health Research Institute, Sun City, Arizona, USA., Sabbagh MN; Barrow Neurologic Institute, Phoenix, Arizona, USA., Long K; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA., Beach TG; Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, USA.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Jul; Vol. 39 (7), pp. 1212-1217. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1002/mds.29783
Abstrakt: Background: While preclinical studies have shown that alpha-synuclein can spread through cell-to-cell transmission whether it can be transmitted between humans is unknown.
Objectives: The aim was to assess the presence of a synucleinopathy in autopsied conjugal couples.
Methods: Neuropathological findings in conjugal couples were categorized as Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease with Lewy bodies (ADLB), incidental Lewy body disease (ILBD), or no Lewy bodies.
Results: Ninety conjugal couples were included; the mean age of death was 88.3 years; 32 couples had no Lewy bodies; 42 couples had 1 spouse with a synucleinopathy: 10 PD, 3 DLB, 13 ADLB, and 16 ILBD; 16 couples had both spouses with a synucleinopathy: in 4 couples both spouses had PD, 1 couple had PD and DLB, 4 couples had PD and ADLB, 2 couples had PD and ILBD, 1 couple had DLB and ADLB, in 3 couples both had ADLB, and 1 couple had ADLB and ILBD. No couples had both spouses with ILBD.
Conclusions: This large series of 90 autopsied conjugal couples found 16 conjugal couples with synucleinopathies, suggesting transmission of synucleinopathy between spouses is unlikely. © 2024 International Parkinson and Movement Disorder Society.
(© 2024 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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