The Relationship Between CYP46A1 Polymorphism and Suicide Risk: A Preliminary Investigation.

Autor: Serna-Rodríguez MF; Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, CP 64460, Monterrey, N.L., México., Cienfuegos-Jiménez O; Centro de Investigación y Desarrollo, en Ciencias de la Salud de la Universidad Autónoma de Nuevo León, CP 64460, Monterrey, N.L., México., Cerda-Flores RM; Facultad de Enfermería, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 1500, Mitras Centro, CP 64460, Monterrey, N.L., Mexico., Marino-Martínez IA; Centro de Investigación y Desarrollo, en Ciencias de la Salud de la Universidad Autónoma de Nuevo León, CP 64460, Monterrey, N.L., México., Hernández-Ordoñez MA; Departamento de Medicina Forense, Hospital Universitario 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Av. Francisco I. Madero y Av. Gonzalitos s/n, Mitras Centro, CP 64460, Monterrey, N.L., Mexico., Ontiveros-Sánchez de la Barquera JA; Departamento de Psiquiatría, Hospital Universitario 'Dr. José Eleuterio González', Universidad Autónoma de Nuevo León, Av. Francisco I. Madero y Av. Gonzalitos s/n, Mitras Centro, CP 64460, Monterrey, N.L., Mexico., Pérez-Maya AA; Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, CP 64460, Monterrey, N.L., México. bioquimicomty@gmail.com.
Jazyk: angličtina
Zdroj: Neuromolecular medicine [Neuromolecular Med] 2024 Apr 09; Vol. 26 (1), pp. 11. Date of Electronic Publication: 2024 Apr 09.
DOI: 10.1007/s12017-024-08779-0
Abstrakt: Suicide is a global public health issue, with a particularly high incidence in individuals suffering from Major Depressive Disorder (MDD). The role of cholesterol in suicide risk remains controversial, prompting investigations into genetic markers that may be implicated. This study examines the association between CYP46A1 polymorphisms, specifically SNPs rs754203 and rs4900442, and suicide risk in a Mexican MDD patient cohort. Our study involved 188 unrelated suicide death victims, 126 MDD patients, and 144 non-suicidal controls. Genotypic and allelic frequencies were assessed using the Real Time-polymerase chain reaction method, and associations with suicide risk were evaluated using chi-square tests. The study revealed significant differences in allelic and genotypic frequencies in rs754203 SNP between suicide death and controls. The CYP46A1 rs754203 genotype G/G was significantly linked with suicide, and the G allele was associated with a higher risk of suicide (OR = 1.370, 95% CI = 1.002-1.873). However, we did not observe any significant differences in genotype distribution or allele frequencies of CYP46A1 rs4900442. Our study suggests that carriers of the CYP46A1 rs754203 G allele (A/G + G/G) may play a role in suicidal behavior, especially in males. Our findings support that the CYP46A1 gene may be involved in susceptibility to suicide, which has not been investigated previously. These results underscore the importance of further research in different populations to elucidate the genetic underpinnings of the role of CYP46A1 in suicide risk and to develop targeted interventions for at-risk populations.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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