Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T cell lymphoma: A retrospective cohort study.

Autor: Hasan I; West Virginia University School of Medicine, Morgantown, West Virginia., Parsons L; West Virginia University School of Medicine, Morgantown, West Virginia., Duran S; West Virginia University School of Medicine, Morgantown, West Virginia., Zinn Z; Department of Dermatology, West Virginia University, Morgantown, West Virginia. Electronic address: zzinn@hsc.wvu.edu.
Jazyk: angličtina
Zdroj: Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2024 Aug; Vol. 91 (2), pp. 255-258. Date of Electronic Publication: 2024 Apr 06.
DOI: 10.1016/j.jaad.2024.03.039
Abstrakt: Background: Dupilumab, a human monoclonal antibody targeting the interleukin 4 alpha receptor, is used for treatment of moderate to severe atopic dermatitis (AD). Previous studies have reported diagnoses of cutaneous T cell lymphoma (CTCL) after dupilumab use.
Objective: Investigate the risk of CTCL after dupilumab use in patients with AD.
Methods: Using the TrinetX database, incidence of cutaneous and lymphoid malignancies including CTCL was compared between a cohort of patients with AD who used dupilumab and a cohort of patients with AD who never used dupilumab. A second analysis excluding prior disease-modifying antirheumatic drug use was performed. Propensity score matching was performed to control for covariates.
Results: An increased risk of CTCL was found in the cohort of AD patients who used dupilumab (odds ratio 4.1003, 95% confidence interval 2.055-8.192). The increased risk persisted after exclusion of prior disease-modifying antirheumatic drug use. Risk was not increased for other cutaneous or lymphoid malignancies. Most (27/41) cases of CTCL were diagnosed more than 1 year after dupilumab use.
Limitations: There is potential for misclassification in the database. Severity of AD could not be assessed. Association between dupilumab and CTCL does not prove causality.
Conclusion: Dupilumab use is associated with an increased risk of CTCL in patients with AD in this cohort.
Competing Interests: Conflicts of interest None disclosed.
(Copyright © 2024 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: