Clinical Features and Predictors of Mortality in Patients With Acute Pulmonary Embolism: A Retrospective Study From Southern Saudi Arabia.

Autor:	Abuelhassan UE; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU.; Department of Respiratory Medicine, Faculty of Medicine, Cairo University, Cairo, EGY., Alsalem AA; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Alshafa FA; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Alshahrani FS; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., AlShahrani MA; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., ALAmri AK; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Alaqil MA; Department of Internal Medicine, King Khalid University Hospital, Abha, SAU., Al Asim AA; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Alsultan EM; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Al Mani SY; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Badawi AG; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Alshehri EF; Department of Medicine, Ministry of Health, Aseer District, Abha, SAU., Alshehri EA; Department of Radiology, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., ALAmri NK; Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Abdalla AM; Department of Pulmonology, Beni Seuf University, Beni Seuf, EGY., Khalaf M; Department of Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, EGY., Ghalyoob TM; Department of Radiology, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU., Elnamaky M; Department of Pulmonary Medicine, Al-Azhar University - Assiut Branch, Assiut, EGY., Mahmoud IM; Department of Critical Care Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, SAU.; Department of Critical Care Medicine, Faculty of Medicine, Cairo University, Cairo, EGY.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Mar 06; Vol. 16 (3), pp. e55623. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).
DOI:	10.7759/cureus.55623
Abstrakt:	Background and Methodology: We aimed to investigate the clinical characteristics, outcomes, and mortality predictors in patients with acute pulmonary embolism (PE). Adult patients who were admitted to the Armed Forces Hospital Southern Region, Khamis Mushait, a large tertiary hospital in Southern Saudi Arabia, with the diagnosis of acute PE were retrospectively examined for the predictors of one-year mortality. Results: The overall in-hospital mortality was 15.6% among 212 patients. In univariate analysis, only age was significantly associated with increased early mortality, whereas age, obesity, presence of active malignancy, hypertension, use of thrombolytics, and Simplified Pulmonary Embolism Severity Index (sPESI) were significantly associated with increased late mortality. By use of binary logistic regression, the presence of obesity (HR 6.010, 95%CI 0.048-16.853, p=0.030), active malignancy (HR 3.040, 95%CI 1.147-8.059, p=0.025), and the use of thrombolytics (HR 8.074, 95%CI 2.719-23.977, p<0.001), were independently significant factors for late (overall) mortality, respectively. Conclusions: Among Saudi Arabian patients in the Southern Region, our data show that age is an independent factor for increased early and late mortality. The presence of obesity, active malignancy, and the use of thrombolytics, were independently significant factors for increased late (one-year) mortality. These factors should be taken into account for risk stratification and decisions on tailored management of patients with PE. Further prospective multicenter studies are needed. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Abuelhassan et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu