Evaluation of antifungal activity of visible light-activated doped TiO 2 nanoparticles.

Autor: Lozano-Rosas R; Instituto Nacional de Astrofísica, Óptica y Electrónica, Departamento de Óptica, Luis Enrique Erro #1 Sta María Tonantzintla, 72840, Puebla, Mexico., Ramos-Garcia R; Instituto Nacional de Astrofísica, Óptica y Electrónica, Departamento de Óptica, Luis Enrique Erro #1 Sta María Tonantzintla, 72840, Puebla, Mexico., Salazar-Morales MF; Instituto Nacional de Astrofísica, Óptica y Electrónica, Departamento de Óptica, Luis Enrique Erro #1 Sta María Tonantzintla, 72840, Puebla, Mexico., Robles-Águila MJ; Centro de Investigación en Dispositivos Semiconductores, Benemérita Universidad Autónoma de Puebla, Instituto de Ciencias, Edificio 105 C, Boulevard 14 Sur y Av. San Claudio, Col. San Manuel, C. P. 72570, Puebla, Puebla, Mexico., Spezzia-Mazzocco T; Instituto Nacional de Astrofísica, Óptica y Electrónica, Departamento de Óptica, Luis Enrique Erro #1 Sta María Tonantzintla, 72840, Puebla, Mexico. terespezzia@inaoep.mx.
Jazyk: angličtina
Zdroj: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2024 May; Vol. 23 (5), pp. 823-837. Date of Electronic Publication: 2024 Apr 03.
DOI: 10.1007/s43630-024-00557-y
Abstrakt: Titanium dioxide (TiO 2 ) is a well-known material for its biomedical applications, among which its implementation as a photosensitizer in photodynamic therapy has attracted considerable interest due to its photocatalytic properties, biocompatibility, high chemical stability, and low toxicity. However, the photoactivation of TiO 2 requires ultraviolet light, which may lead to cell mutation and consequently cancer. To address these challenges, recent research has focused on the incorporation of metal dopants into the TiO 2 lattice to shift the band gap to lower energies by introducing allowed energy states within the band gap, thus ensuring the harnessing of visible light. This study presents the synthesis, characterization, and application of TiO 2 nanoparticles (NPs) in their undoped, doped, and co-doped forms for antimicrobial photodynamic therapy (APDT) against Candida albicans. Blue light with a wavelength of 450 nm was used, with doses ranging from 20 to 60 J/cm 2 and an NP concentration of 500 µg/ml. It was observed that doping TiO 2 with Cu, Fe, Ag ions, and co-doping Cu:Fe into the TiO 2 nanostructure enhanced the visible light photoactivity of TiO 2 NPs. Experimental studies were done to investigate the effects of different ions doped into the TiO 2 crystal lattice on their structural, optical, morphological, and chemical composition for APDT applications. In particular, Ag-doped TiO 2 emerged as the best candidate, achieving 90-100% eradication of C. albicans.
(© 2024. The Author(s), under exclusive licence to European Photochemistry Association, European Society for Photobiology.)
Databáze: MEDLINE
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