Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis.

Autor:	Schoberleitner I; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria., Faserl K; Protein Core Facility, Institute of Medical Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Tripp CH; Department of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria., Pechriggl EJ; Department of Anatomy, Histology and Embryology, Institute of Clinical and Functional Anatomy, Medical University of Innsbruck, Innsbruck, Austria., Sigl S; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria., Brunner A; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.; INNPATH GmbH, Tirol Kliniken, Innsbruck, Austria., Zelger B; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria., Hermann-Kleiter N; Institute of Cell Genetics, Department for Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Baier L; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria., Steinkellner T; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria., Sarg B; Protein Core Facility, Institute of Medical Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria., Egle D; Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria., Brunner C; Department of Obstetrics and Gynecology, Medical University of Innsbruck, Innsbruck, Austria., Wolfram D; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Mar 19; Vol. 15, pp. 1342895. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1342895
Abstrakt:	Excessive fibrous capsule formation around silicone mammary implants (SMI) involves immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host responses, worsens with specific implant topographies. Our study with 10 patients investigated intra- and inter-individually, reduced surface roughness effects on disease progression, wound responses, chronic inflammation, and capsular composition. The results illuminate the significant impact of surface roughness on acute inflammatory responses, fibrinogen accumulation, and the subsequent fibrotic cascade. The reduction of surface roughness to an average roughness of 4 μm emerges as a promising approach for mitigating detrimental immune reactions, promoting healthy wound healing, and curbing excessive fibrosis. The identified proteins adhering to rougher surfaces shed light on potential mediators of pro-inflammatory and pro-fibrotic processes, further emphasizing the need for meticulous consideration of surface design. The composition of the implant capsule and the discovery of intracapsular HSP60 expression highlight the intricate web of stress responses and immune activation that can impact long-term tissue outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Schoberleitner, Faserl, Tripp, Pechriggl, Sigl, Brunner, Zelger, Hermann-Kleiter, Baier, Steinkellner, Sarg, Egle, Brunner and Wolfram.)
Databáze:	MEDLINE
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