| Autor: |
Youssif YM; Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt., Elhagali GAM; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt., Zahran MA; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt., Ahmed FA; Medicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt., Ragab A; Chemistry Department, Faculty of Science (Boys), Al-Azhar University, Cairo, Egypt.; Department for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2024 Apr 01, pp. 1-9. Date of Electronic Publication: 2024 Apr 01. |
| DOI: |
10.1080/14786419.2024.2335666 |
| Abstrakt: |
Ziziphora capitata (Lamiaceae family) aerial parts extract contains 57 metabolites, including flavonoids, phenolic acids, anthocyanins, and coumarins, as assessed by UPLC-QTOF-MS/MS. Successive extracts (hexane, chloroform, ethyl acetate, ethanol 95%, and water) were tested in vitro cytotoxic activity against HepG-2, MCF-7, HCT-116, A549, and PC3 cell lines. The results revealed that hexane extract exhibited the most potent cytotoxic activity among PC3 and A549 cell lines, IC 50 = 47.1 ± 1.75 and 49.2 ± 1.08 µg/mL compared to Vinblastine IC 50 = 42.47 ± 1.95 and 24.64 ± 1.18 µg/mL, respectively, and had a moderate impact on the remaining cell lines. Moreover, the chloroform and ethyl acetate extracts exhibited moderate affinity among all tested cell lines. Furthermore, the total phenolic and flavonoid contents were assessed. The molecular docking simulation was performed inside the effective sites of VEGFR-2 and TS as anticancer targets for the top ten phytochemicals. The results showed higher binding energy values for VEGFR-2 than for TS compared to vinblastine and co-crystallized ligands. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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