Intrauterine insemination: prognostic factors.

Autor:	Dias CMF; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil., Vitorino GBT; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil., Furlan SMP; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil., Reis RMD; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil.; National Institute of Hormones and Women's Health, CNPq, Brazil., Silva ACJSRE; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil.; National Institute of Hormones and Women's Health, CNPq, Brazil., Mendes MC; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil., Ferriani RA; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil.; National Institute of Hormones and Women's Health, CNPq, Brazil., Navarro PA; Sector of Human Reproduction, Department of Gynecology and Obstetrics - Ribeirão Preto Medical School, University of São Paulo, Brazil.; National Institute of Hormones and Women's Health, CNPq, Brazil.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2024 Jun 01; Vol. 28 (2), pp. 254-262. Date of Electronic Publication: 2024 Jun 01.
DOI:	10.5935/1518-0557.20240017
Abstrakt:	Objective: To evaluate the impact of possible maternal and paternal prognostic factors and ovarian stimulation protocols on clinical pregnancy and live birth rates in intrauterine insemination (IUI) cycles. Methods: Retrospective observational study of 341 IUI cycles performed from January 2016 to November 2020 at the Assisted Reproduction Service of the Clinics Hospital of the Ribeirão Preto Medical School, University of São Paulo. Clinical pregnancy and live birth rates and their potential prognostic factors were evaluated. Wilcoxon's non-parametric test was used to compare quantitative variables, and the chi-square test to compare qualitative variables, adopting a significance level of p<0.05. A logistic regression model was performed to verify which exploratory variables are predictive factors for pregnancy outcome. Results: The ovulation induction protocol using gonadotropins plus letrozole (p=0.0097; OR 4.3286, CI 1.3040 - 14.3684) and post-capacitation progressive sperm ≥ 5million/mL (p=0.0253) showed a statistically significant correlation with the live birth rate. Female and male age, etiology of infertility, obesity, multifollicular growth, endometrial thickness ≥ 7 mm, and time between human chorionic gonadotropin administration and IUI performance were not associated with the primary outcomes. In the group of patients with ideal characteristics (women aged< 40 years, BMI < 30 kg/m2, antral follicle count ≥ 5, partner aged< 45 years, and post-capacitation semen with progressive spermatozoa ≥ 5 million/mL), the rate of clinical pregnancy was 14.8%, while that of live birth, 9.9%. Conclusions: In this study, the ovulation induction protocol with gonadotropins plus letrozole and post-capacitation progressive sperm ≥ 5 million/mL were the only variables that significantly correlated with intrauterine insemination success.
Databáze:	MEDLINE
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