Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery.

Autor: Nguyen NTT; Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University 298-300A Nguyen Tat Thanh, District 4 Ho Chi Minh City 755414 Vietnam ntcduyen@ntt.edu.vn tranuv@gmail.com tranvt@ntt.edu.vn.; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT) 268 Ly Thuong Kiet Street, District 10 Ho Chi Minh City Vietnam.; Vietnam National University Ho Chi Minh City Linh Trung Ward, Thu Duc District Ho Chi Minh City Vietnam., Nguyen TTT; Department of Chemical Engineering and Processing, Nong Lam University Thu Duc District Ho Chi Minh City 700000 Vietnam., Ge S; Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Materials Science and Engineering, Nanjing Forestry University Nanjing 210037 China., Liew RK; Higher Institution Centre of Excellence (HICoE), Institute of Tropical Aquaculture and Fisheries (AKUATROP), Universiti Malaysia Terengganu 21030, Kuala Nerus Terengganu Malaysia.; NV Western PLT No. 208B, Second Floor, Macalister Road Georgetown 10400 Penang Malaysia., Nguyen DTC; Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University 298-300A Nguyen Tat Thanh, District 4 Ho Chi Minh City 755414 Vietnam ntcduyen@ntt.edu.vn tranuv@gmail.com tranvt@ntt.edu.vn., Tran TV; Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University 298-300A Nguyen Tat Thanh, District 4 Ho Chi Minh City 755414 Vietnam ntcduyen@ntt.edu.vn tranuv@gmail.com tranvt@ntt.edu.vn.
Jazyk: angličtina
Zdroj: Nanoscale advances [Nanoscale Adv] 2024 Mar 06; Vol. 6 (7), pp. 1800-1821. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).
DOI: 10.1039/d3na01075a
Abstrakt: Metal-organic frameworks (MOFs), a burgeoning class of coordination polymers, have garnered significant attention due to their outstanding structure, porosity, and stability. They have been extensively studied in catalysis, energy storage, water harvesting, selective gas separation, and electrochemical applications. Recent advancements in post-synthetic strategies, surface functionality, and biocompatibility have expanded the application scope of MOFs, particularly in various biomedical fields. Herein, we review MOF-based nanomaterials bioimaging nanoplatforms in magnetic resonance imaging, computed tomography, and fluorescence imaging. MOFs serve as the foundation for biosensors, demonstrating efficiency in sensing H 2 O 2 , tumor biomarkers, microRNA, and living cancer cells. MOF-based carriers are well designed in drug delivery systems and anticancer treatment therapies. Additionally, we examine the challenges and prospects of MOFs in surface modification, release of metal ions, and interaction with intracellular components, as well as their toxicity and long-term effects.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE